Results 271 to 280 of about 727,025 (334)

DNA Repair Enzymes in Mammalian Cells

, 1977
In the past two decades, considerable strides have been made in understanding the phenomenon of DNA damage and its repair at all levels of biological organization. Studies on living cells using prokaryote models have been extensively reviewed by a number of authors (Town et al., 1973; Setlow and Setlow, 1972; Smith, 1971; Witkin, 1969; Hanawalt, 1968 ...
E. Friedberg, K. Cook, J. Duncan, K. Mortelmans   +3 more
semanticscholar   +2 more sources

DNA Repair Enzymes

Current Protocols in Molecular Biology, 2008
AbstractIn vivo DNA damage impacts the genetic stability of an organism; therefore, multiple pathways utilizing a large number of enzymes have evolved to repair DNA damage. This unit focuses on enzymes involved in base excision repair (BER). The BER enzymes possessing N‐glycosylase activity can find and remove a wide variety of damaged bases in a sea ...
Thomas C, Evans, Nicole M, Nichols
openaire   +2 more sources

EP300-HDAC1-SWI/SNF functional unit defines transcription of some DNA repair enzymes during differentiation of human macrophages.

Biochimica et Biophysica Acta. Gene Regulatory Mechanisms, 2019
Differentiation of human macrophages predisposes these cells to numerous tasks, i.e. killing invading pathogens, and this entails the need for enhanced intracellular defences against stress, including conditions that may increase DNA damage.
J. Pietrzak, T. Płoszaj, Łukasz Pułaski, A. Robaszkiewicz   +3 more
semanticscholar   +1 more source

AND Logic Gate-Regulated DNAzyme Nanoflower for Monitoring the Activity of Multiple DNA Repair Enzymes.

Analytical Chemistry
Despite the progress that has been made in diverse DNA-based nanodevices to in situ monitor the activity of the DNA repair enzymes in living cells, the significance of improving both the sensitivity and specificity has remained largely neglected and ...
Wei-Jia Zeng, Xiao-Ran Li, Wei Liu, Ruo Yuan, W. Liang, Ying Zhuo   +5 more
semanticscholar   +1 more source

Tuberin regulates the DNA repair enzyme OGG1

American Journal of Physiology-Renal Physiology, 2008
The tuberous sclerosis complex (TSC) is caused by defects in one of two tumor suppressor genes, TSC-1 or TSC-2. The TSC-2 gene encodes tuberin, a protein involved in the pathogenesis of kidney tumors, both angiomyolipomas and renal cell carcinomas. We investigated a potential role for tuberin in regulating a key DNA repair pathway.
Samy L, Habib, Daniel J, Riley, Lenin, Mahimainathan, Basant, Bhandari, Goutam Ghosh, Choudhury, Hanna E, Abboud   +5 more
openaire   +2 more sources

Detection of DNA point mutations with DNA mismatch repair enzymes

Carcinogenesis, 1994
We have developed a simple and reliable procedure to screen gene mutations using DNA mismatch repair (MR) specific mut Y enzyme of Escherichia coli and thymidine DNA glycosylase from HeLa cells. The mut Y enzyme cleaves A of G/A mismatches in DNA duplex and thymidine glycosylase cleaves T at G/T mismatches.
I C, Hsu, Q, Yang, M W, Kahng, J F, Xu
openaire   +2 more sources

Aberrant activity of the DNA repair enzyme AlkB

Journal of Inorganic Biochemistry, 2004
Escherichia coli AlkB is a DNA/RNA repair enzyme containing a mononuclear Fe(II) site that couples the oxidative decomposition of alpha-ketoglutarate (alphaKG) to the hydroxylation of 1-methyladenine or 3-methylcytosine lesions in DNA or RNA, resulting in release of formaldehyde and restoration of the normal bases.
Timothy F, Henshaw, Michael, Feig, Robert P, Hausinger   +2 more
openaire   +2 more sources

DNA mismatch repair enzymes: Genetic defects and autoimmunity

Clinica Chimica Acta, 2015
DNA mismatch repair (MMR) is one of the several DNA repair pathways conserved from bacteria to humans. The primary function of MMR is to eliminate the mismatch of base-base insertions and deletions that appear as a consequence of DNA polymerase errors at DNA synthesis.
Yoshinao, Muro, Kazumitsu, Sugiura, Tsuneyo, Mimori, Masashi, Akiyama   +3 more
openaire   +2 more sources

DNA Repair Enzymes in Hyperthermophilic Archaea

1998
The presence of hyperthermophilic microorganisms in hydrothermal environments at temperatures above 90°C is now well established (Stetter, 1990). In fact, isolates from deep sea marine hydrothermal vents can grow optimally under pressure at temperatures up to 113°C (Blochl et al., 1997).
Jocelyne Diruggiero, Frank T. Robb
openaire   +1 more source

Lymphocyte DNA adducts and polymorphism in the DNA repair enzyme XPD

Biomarkers, 2001
The effect of genetic polymorphism of DNA repair enzyme on the DNA adduct levels was evaluated in this study. We explored the relationship between polymorphism in the nucleotide excision repair enzyme XPD and DNA adduct levels in lymphocytes. Lymphocyte DNA adducts were measured by a (32.)
M, Ichiba, J, Zhang, C, Kiyohara, Y, Nakanishi, K, Takayama, N, Hara, M, Enoki, K, Tomokuni   +7 more
openaire   +2 more sources