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DNA Repair Enzymes in Hyperthermophilic Archaea
1998The presence of hyperthermophilic microorganisms in hydrothermal environments at temperatures above 90°C is now well established (Stetter, 1990). In fact, isolates from deep sea marine hydrothermal vents can grow optimally under pressure at temperatures up to 113°C (Blochl et al., 1997).
Jocelyne Diruggiero, Frank T. Robb
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Lymphocyte DNA adducts and polymorphism in the DNA repair enzyme XPD
Biomarkers, 2001The effect of genetic polymorphism of DNA repair enzyme on the DNA adduct levels was evaluated in this study. We explored the relationship between polymorphism in the nucleotide excision repair enzyme XPD and DNA adduct levels in lymphocytes. Lymphocyte DNA adducts were measured by a (32.)
M, Ichiba +7 more
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DNA Repair Enzymes in Mammalian Cells
1977In the past two decades, considerable strides have been made in understanding the phenomenon of DNA damage and its repair at all levels of biological organization. Studies on living cells using prokaryote models have been extensively reviewed by a number of authors (Town et al., 1973; Setlow and Setlow, 1972; Smith, 1971; Witkin, 1969; Hanawalt, 1968 ...
Errol C. Friedberg +3 more
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Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase
DNA Repair, 2013Human nuclear uracil-DNA glycosylase UNG2 is essential for post-replicative repair of uracil in DNA, and UNG2 protein and mRNA levels rapidly decline in G2/M phase. Previous work has demonstrated regulation of UNG2 at the transcriptional level, as well as by protein phosphorylation and ubiquitylation. UNG2 mRNA, encoded by the UNG gene, contains a long
Siv A, Hegre +5 more
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Enzymes involved in the repair of damaged DNA
Archives of Biochemistry and Biophysics, 1981The progress that has been made in our understanding of the enzymatic mechanisms by which modified nucleotides in DNA are recognized and repaired is due, in part, to the developments that have been made in photobiology and photochemistry. It was these areas of activity that led to the identification of the primary ultraviolet irradiation photoproducts ...
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Liposome-Encapsulated Enzymes for DNA Repair
1992Skin cancer is the most common cancer in the Western world, and strong epidemiological evidence links solar UV exposure to the vast majority of these cancers [11]. Our current understanding of the multi-step neoplastic process has focused on DNA damage as an initiating event.
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DNA Repair: Genes, Enzymes, Patients, and Mouse Models
1997All organisms have evolved intricate networks of complementary DNA repair systems, enabling them to counteract a large variety of DNA damages. Among these, the cyclobutane pyrimidine dimers (CPDs) and the 6,4-pyrimidine-pyrimidone photoproducts (64PP) are certainly the most relevant since they are produced in massive amounts in human skin exposed to ...
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Enzymes Involved in the Repair of DNA
1974Publisher Summary This chapter describes enzymes that have the potential to act upon irradiated DNA during different phases of an excision repair cycle. The duplex structure of DNA is maintained by relatively weak hydrogen bonds, which can be broken reversibly by either temperature or extremes in pH.
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