Results 251 to 260 of about 225,059 (304)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Skin Cancer Prevention and Antiaging: Role of Nicotinamide. [PDF]

Int J Mol Sci
Moro F, Panebianco ASI, Bartolocci V, Capone A, Di Guardo A, Hyeraci M, Gemma GPA, Di Lella G, Colonna L, Ricci F, Dellambra E, Fania L.   +11 more
europepmc   +1 more source

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

The glycolysis-lactylation axis: a metabolic-epigenetic driver of immunosuppression and therapy resistance in cancer. [PDF]

Front Immunol
Tan S, Zhang W, Ding Y, Liu J, Zhu M, Luo X, Cai J, Zeng H.   +7 more
europepmc   +1 more source

Metabolic drivers of genome instability in cancer: mechanisms and therapeutic opportunities. [PDF]

Exp Hematol Oncol
Wang YS, Qian LH, Liu CC, Yu KD.
europepmc   +1 more source

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment. [PDF]

MedComm (2020)
Li Q, Sun Y, Lin S, Yuan Q.
europepmc   +1 more source

Manipulating DNA repair and the DNA damage response to improve cancer therapy. [PDF]

NAR Cancer
Lan L, Fouquerel E.
europepmc   +1 more source

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DNA-repair enzymes

Current Opinion in Structural Biology, 1997
Recent crystallographic studies of DNA-repair enzymes have provided the structural basis for the recognition of damaged DNA. The results imply that flipping out of the base is a common and crucial event in DNA repair. Two classes of repair enzymes that recognize distinct types of damage may exist.
Dmitry G Vassylyev, Kosuke Morikawa, K Morikawa   +2 more
exaly   +3 more sources