Results 161 to 170 of about 3,431,424 (346)
Correlation of gamma-ray inactivation and strand scission in the replicative form of phi-X174 bacteriophage DNA. [PDF]
, 1967 William D. Taylor, William Ginoza
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Eukaryotic DNA Replication Fork.
Annual Review of Biochemistry, 2017 P. Burgers, T. Kunkel
semanticscholar +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
REPLICATIVE FRAGMENTATION IN T4 BACTERIOPHAGE DNA, II. BIPARENTAL MOLECULAR RECOMBINATION [PDF]
, 1964 Andrzej W. Kozinski, P B Kozinski
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
EVENTS OCCURRING DURING THE REPLICATION OF BACTERIOPHAGE T4 DNA [PDF]
, 1969 Paul D. Scotti
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Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
wiley +1 more source
REPLICATION OF NUCLEOLUS-ASSOCIATED DNA DURING "G2 PHASE" IN PHYSARUM POLYCEPHALUM [PDF]
, 1969 E. Guttes, Sophie Guttes
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