Results 181 to 190 of about 710,489 (317)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Continuously tunable multistability in DNA replication networks. [PDF]

Nat Commun
Zhong R, Fu Y, Jiang S, Wang S, Yue L, Tan W.   +5 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Direct non transcriptional role of the CCAAT-factor NF-Y in DNA replication

, 2016
The heterotrimeric transcription factor NF-Y plays a pioneer role in the transcriptional control of promoters containing the CCAAT-box, among which genes involved in cell cycle regulation.
Roberto, Mantovani, Julia, Neusiedler, IMBRIANO, Carol, Benoit, Miotto, Diletta, Dolfini, Etienne, Schwob, BENATTI, Paolo, Marjorie, Drac, BELLUTI, SILVIA, Julian Blow, J.   +9 more
core  

PAF15-PCNA exhaustion governs the strand-specific control of DNA replication. [PDF]

Nature
Chhetri G, Badugu SB, Petriman NA, Petersen MB, Güller AS, Fajri N, Coulée M, Pitchai GP, Novotný J, Larsen FT, Møller AF, Ebbesen MF, Ravnsborg T, Yadav AK, Balarasa B, Lunding A, Polasek-Sedlackova H, Jensen ON, Ravnskjaer K, Brewer JR, Madsen JGS, Petryk N, Andersen JS, Somyajit K.   +23 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

TOP1 and TOP2 complementarily maintain DNA replication fork progression in vertebrates. [PDF]

J Biol Chem
Umemura K, Ooka M, Sojo M, Seki M, Xia M, Hirota K, Abe T.   +6 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Investigations of the molecular determinants of maize streak virus replication

, 1999
Includes bibliographical references.Geminiviruses replicate via a rolling circle mechanism, which initiates at the origin of replication located within the long intergenic region (LIR).
Willment, Janet Anne
core  

Minute amounts of helicase-deficient truncated RECQL4 are sufficient for DNA replication. [PDF]

EMBO Rep
Buco PAV, Castillo-Tandazo W, Chalk AM, Pilcher C, Holien JK, Heierhorst J, Tan TY, Koren A, Smeets MF, Walkley CR.   +9 more
europepmc   +1 more source