Results 181 to 190 of about 649,005 (267)

Automated mapping of DNA replication fork progression in human cells with ForkML. [PDF]

Nat Commun
Rojat V, Ciardo D, Tourancheau A, Proux F, Jean E, Arbona JM, Audit B, Millot GA, Bonhomme F, Arimondo PB, Hyrien O, Le Tallec B.   +11 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

HCMV infection depends on EGLN1-mediated mitochondrial activation to increase dNTP pools for viral DNA replication. [PDF]

Cell Rep
Simpson LA, Dunn DM, Fales W, Moore ZJ, Ciesla JH, Waild NC, Raymonda MH, Harris IS, Munger J.   +8 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Termination of DNA replication drives genomic instability via multiple mechanisms. [PDF]

Nucleic Acids Res
Goodall DJ, Dimude JU, Hashemloo MA, Dunbar EL, Grigoryan I, Upton AL, Bolt EL, Rudolph CJ.   +7 more
europepmc   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Reconstituting transcription-translation-coupled DNA replication within complex in vitro biological systems. [PDF]

Nat Commun
Zheng X, Gao W, Liu WQ, Zhang Y, Huang S, Ji X, Lu Y, Liu Y, Ling S, Li J.   +9 more
europepmc   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

A genome language model for mapping DNA replication origins

Pfuderer PL, Berkemeier F, Nassar J, Crisp A, Jaworski JJ, Moore J, Sale JE, Boemo MA.   +7 more
europepmc   +1 more source

Mitochondrial DNA replication is regulated by endoplasmic reticulum-mitochondrial contact sites, the mitochondrial calcium uniporter, and manganese. [PDF]

Nucleic Acids Res
Lopez de Arbina A, Zamudio-Ochoa A, Muñoz-Oreja M, Perez-Rodriguez D, Mosqueira-Martín L, Lasalandra R, Villar-Fernandez M, Fernandez-Pelayo U, Rodriguez-Gomez L, Lee S, Gil-Bea F, Osinalde N, Vallejo-Illaramendi A, Temiakov D, Spinazzola A, Holt IJ.   +15 more
europepmc   +1 more source