Results 211 to 220 of about 710,489 (317)

Mechanisms of chromosomal DNA replication in Escherichia coli and Bacillus subtilis. [PDF]

FEMS Microbiol Rev
Torres R, Carrasco B, Ayora S, Alonso JC.   +3 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Torsion is a dynamic regulator of DNA replication stalling and reactivation. [PDF]

Nat Commun
Jia X, Gao X, Zhang S, Inman JT, Hong Y, Singh A, Rashid F, Berger JM, Patel SS, Wang MD.   +9 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Aspects of DNA Replication

Cold Spring Harbor Symposia on Quantitative Biology, 1979
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Evaluation of non-canonical p53 functions in DNA replication and recombination for variant classification. [PDF]

Cell Death Dis
Jansche R, Heitmeir B, Faust U, Pospiech H, Sutter C, Albig C, Hennig F, Janni W, Schmutzler R, Hauke J, Joerger AC, Wiesmüller L.   +11 more
europepmc   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Author Correction: Structures of the human leading strand Polε–PCNA holoenzyme

Nature Communications
Qing He, Feng Wang, Nina Y. Yao, Michael E. O’Donnell, Huilin Li   +4 more
doaj   +1 more source

Automated mapping of DNA replication fork progression in human cells with ForkML. [PDF]

Nat Commun
Rojat V, Ciardo D, Tourancheau A, Proux F, Jean E, Arbona JM, Audit B, Millot GA, Bonhomme F, Arimondo PB, Hyrien O, Le Tallec B.   +11 more
europepmc   +1 more source