Results 31 to 40 of about 3,431,424 (346)
Mitochondrial DNA replication in mammalian cells: overview of the pathway
Essays in Biochemistry, 2018 Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA genome and a dedicated DNA replication machinery is required for its maintenance.
M. Falkenberg
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SARS-CoV-2: from its discovery to genome structure, transcription, and replication
Cell & Bioscience, 2021 SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has a single-stranded, positive-sense RNA (+RNA) genome of ~ 29.9 kb and exhibits significant ...
Ayslan Castro Brant +4 more
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Molecular Docking for the Development of Alternative Therapies against Leishmaniasis
Chemistry Proceedings, 2023 Topoisomerases play a pivotal role in regulating the topological structure of DNA during fundamental processes such as transcription, DNA repair, or DNA replication; because of this, topoisomerases are biological targets in pathogenic microorganisms or ...
Juan Diego Guarimata +3 more
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Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells
Retrovirology, 2023 Background SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is not restricted in cycling cells and it has been proposed that this is due to phosphorylation of SAMHD1 at T592 in these ...
Ming-Han C. Tsai +8 more
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Fidelity of DNA replication—a matter of proofreading
Current Genetics, 2018 DNA that is transmitted to daughter cells must be accurately duplicated to maintain genetic integrity and to promote genetic continuity. A major function of replicative DNA polymerases is to replicate DNA with the very high accuracy.
Anna Bębenek, Izabela Ziuzia-Graczyk
semanticscholar +1 more source
Case Reports in Genetics, 2021 Mitochondrial DNA (mtDNA) depletion syndromes are a group of autosomal recessive disorders associated with a spectrum of clinical diseases, which include progressive external ophthalmoplegia (PEO).
Justin Kurtz +4 more
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Virus DNA Replication and the Host DNA Damage Response.
Annual Review of Virology, 2018 Viral DNA genomes have limited coding capacity and therefore harness cellular factors to facilitate replication of their genomes and generate progeny virions.
M. Weitzman, Amélie Fradet-Turcotte
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Conservative DNA Replication [PDF]
Nature Reviews Molecular Cell Biology, 2014 Thanos D. Halazonetis describes the discovery that break-induced replication is conservative in budding yeast.
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Replication of G Quadruplex DNA
Genes, 2019 A cursory look at any textbook image of DNA replication might suggest that the complex machine that is the replisome runs smoothly along the chromosomal DNA.
L. K. Lerner, J. Sale
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Mechanisms of DNA replication [PDF]
Current Opinion in Chemical Biology, 2000 Advances in recent years have led to exciting new ideas about the initiation, regulation and coordination of DNA replication. Structural studies have yielded fascinating glimpses of replisome action. In addition, the involvement of replication proteins in other cellular processes has blurred the lines between replication, repair and recombination.
Megan J. Davey, Mike O'Donnell
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