Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability
Genes, 2016 Successful cell proliferation requires efficient and precise genome duplication followed by accurate chromosome segregation. The Cdc10-dependent transcript 1 protein (Cdt1) is required for the first step in DNA replication, and in human cells Cdt1 is ...
Pedro N Pozo, J. Cook
semanticscholar +1 more source
Emerging Roles for Ciz1 in Cell Cycle Regulation and as a Driver of Tumorigenesis [PDF]
, 2016 Precise duplication of the genome is a prerequisite for the health and longevity of multicellular organisms. The temporal regulation of origin specification, replication licensing, and firing at replication origins is mediated by the cyclin-dependent ...
Copeland, Nikki A. +3 more
core +2 more sources
Xenopus cell-free extracts and their contribution to the study of DNA replication and other complex biological processes [PDF]
, 2016 Here we discuss the important contributions that cell-free extracts have made to the study of complex biological processes. We provide a brief history of how cell-free extracts of frog eggs were developed to avoid many of the problems that can arise from
Blow, J. Julian, Laskey, Ronald A.
core +1 more source
Die Rolle der AAA+ -ATPase p97 in der Regulation der Aktivierung des Zellzykluskontrollpunkt nach DNA Schaden [PDF]
, 2015 Der Zellzyklus ist ein streng regulierter Prozess, welcher die exakte Replikation und Segregation des genetisches Materials in zwei Tochterzellen reguliert.
Riemer, Anne
core
Emergent properties of the G1/S network [PDF]
, 2010 Tato práce se zabývá buněčným cyklem kvasinky Saccgaromyces cerevisiae. Oblastí našeho zájmu je přechod mezi G1 a S fází, kde je naším cílem identifikovat velikosti buňky v době počátku DNA replikace.
Dražková, Jana
core
Nuclear DNA Replication in Trypanosomatids:There Are No Easy Methods for Solving Difficult Problems [PDF]
, 2017 In trypanosomatids, etiological agents of devastating diseases, replication is robust and finely controlled to maintain genome stability and function in stressful environments.
Albalat +103 more
core +4 more sources
Journal of Biological Chemistry, 2018 During DNA replication or repair, the DNA polymerase cofactor, proliferating cell nuclear antigen (PCNA), homotrimerizes and encircles the replicating DNA, thereby acting as a DNA clamp that promotes DNA polymerase processivity. The formation of the PCNA
Feng Leng +9 more
semanticscholar +1 more source
DNA Rereplication Is Susceptible to Nucleotide-Level Mutagenesis. [PDF]
, 2019 The sources of genome instability, a hallmark of cancer, remain incompletely understood. One potential source is DNA rereplication, which arises when the mechanisms that prevent the reinitiation of replication origins within a single cell cycle are ...
Bui, Duyen T, Li, Joachim J
core
An ORC/Cdc6/MCM2-7 Complex Is Formed in a Multistep Reaction to Serve as a Platform for MCM Double-Hexamer Assembly [PDF]
, 2013 In Saccharomyces cerevisiae and higher eukaryotes, the loading of the replicative helicase MCM2-7 onto DNA requires the combined activities of ORC, Cdc6, and Cdt1. These proteins load MCM2-7 in an unknown way into a double hexamer around DNA.
Evrin, C +9 more
core +1 more source
Cell autonomous regulation of herpes and influenza virus infection by the circadian clock. [PDF]
, 2016 Viruses are intracellular pathogens that hijack host cell machinery and resources to replicate. Rather than being constant, host physiology is rhythmic, undergoing circadian (∼24 h) oscillations in many virus-relevant pathways, but whether daily rhythms ...
Edgar, Rachel S +6 more
core +2 more sources