Results 181 to 190 of about 465,116 (357)

The fragment structure of a putative HsdR subunit of a type I restriction enzyme from Vibrio vulnificus YJ016: implications for DNA restriction and translocation activity [PDF]

Among four types of bacterial restriction enzymes that cleave a foreign DNA depending on its methylation status, type I enzymes composed of three subunits are interesting because of their unique DNA cleavage and translocation mechanisms performed by the ...
Andersen, Berge, Bird, Bond, Brünger, Calisto, Chin, Davies, Deibert, Dryden, Dryden, Durr, Emsley, Eryilmaz, Fan, Firman, Horton, Hyun-Ju Lee, Janscak, Janscak, Janscak, Jeong-Sun Kim, Ji-Woo Choi, Jindrova, Jones, Kennaway, Kim, Kim, Kosuke Nishi, Lapkouski, Laskowski, Li, Machius, Murray, Nguyen, Nguyen To Uyen, Obarska-Kosinska, Otwinowski, Richards, Seidel, Shi, Sisakova, Sistla, Sisáková, Stanley, Studier, Suk-Youl Park, Taylor, Terwilliger, Terwilliger, Velankar, Wah, Wilson, Winn   +53 more
core   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Comparison of neutralization and DNA restriction enzyme methods for typing clinical isolates of human adenovirus [PDF]

, 1985
K H Fife, R Ashley, Anthony F. Shields, Deborah Salter, Joel D. Meyers, Lawrence Corey   +5 more
openalex   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A Possible Mechanism of DNA to DNA Transcription in Eukaryotic Cells : Endonuclease Dependent Transcript Cutout [PDF]

arXiv, 2016
We previously proposed the existence of DNA to DNA transcription in eukaryotic cells, but the mechanism by which single-stranded DNA (ssDNA) transcript is produced and released from the genome remains unknown. We once speculated that the mechanism of DNA to DNA transcription might be similar to that of DNA to RNA transcription, but now we propose that ...
arxiv  

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source

Asymmetric DNA recognition by the OkrAI endonuclease, an isoschizomer of BamHI [PDF]

Restriction enzymes share little or no sequence homology with the exception of isoschizomers, or enzymes that recognize and cleave the same DNA sequence.
A. K. Aggarwal, A. M. Hartline, A. Ummat, Aggarwal, Br  nger, Catterall, Chevalier, Collaborative Computational Project Number, E. S. Vanamee, Grones, H. Viadiu, Hensley, Hwang, Kim, King, Lee, Lu, Lukacs, Murakami, Newman, Newman, Otwinowski, Pingoud, S.-H. Chan, S.-y. Xu, Selent, Vagin, Viadiu, Viadiu, Whitaker, Winkler, Xu, Xu, Xu   +33 more
core   +2 more sources

The use of phosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA [PDF]

, 1985
John W. Taylor, Walter Schmidt, Richard Cosstick, And̀rzej Okruszek, Fritz Eckstein   +4 more
openalex   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

A design proposal of the reverse DNA polymerase (3'-5' direction) [PDF]

arXiv, 2013
DNA Polymerase is an enzyme that participates in the process of DNA replication. In general, forward DNA polymerase moves along the template strand in a 3'-5' direction, and the daughter strand is formed in a 5'-3' direction. This paper theoretically analyzes the mechanism of forward DNA polymerase, and gives the design proposal of a new reverse DNA ...
arxiv