Results 251 to 260 of about 390,387 (330)

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Association of LEPR Gene Polymorphisms With Youth-Onset Diabetes in Bangladesh. [PDF]

Cureus
Shayedat-Ullah M, Sultana N, Hasan M, Amin USM, Rahman TA, Roy I, Rayhan M, Sutradhar PC, Salimullah M, Hasanat MA.   +9 more
europepmc   +1 more source

Tension-dependent DNA cleavage by restriction endonucleases: Two-site enzymes are “switched off” at low force

, 2006
Gregory J. Gemmen, Rachel Millin, Douglas E. Smith   +2 more
openalex   +1 more source

Implementing BMP‐7 Chemically Modified RNA for Bone Regeneration with 3D Printable Hyaluronic Acid‐Collagen Granular Gels

Advanced Healthcare Materials, EarlyView.
This study developed 3D‐printable THA‐Col microgels for delivering BMP‐7 cmRNA. The key result is that hMSCs transfected on the biomaterials showed BMP‐7 secretion levels comparable to pre‐transfected hMSCs, therefore introducing a cmRNA‐activated matrix to promote bone healing.
Daphne van der Heide, Claudia del Toro Runzer, Elena Della Bella, Christian Plank, Martijn van Griensven, Elizabeth Rosado Balmayor, Martin J. Stoddart, Matteo D'Este   +7 more
wiley   +1 more source

Long-read plasmid sequencing strategy for evaluating intrinsic instability of tandem gene arrays. [PDF]

MicroPubl Biol
Takesue H, Okada S, Ito T.
europepmc   +1 more source

Enhancing the Pharmacokinetics of Aptamers: Targeting AXL In Vivo Using a Bottlebrush Polymer‐Conjugated Aptamer

Advanced Healthcare Materials, EarlyView.
A phosphodiester‐backboned bottlebrush polymer (pacDNA) engineered for aptamer delivery is presented. This design enhances aptamer stability, plasma pharmacokinetics, and target engagement in vivo. In AXL‐driven cancer models, pacDNA inhibits AXL signaling and reduces tumor growth, highlighting the promise of precision polymer scaffolds in aptamer ...
Tingyu Sun, Jiachen Lin, Chenyang Xue, Yuyan Wang, Peiru Chen, Yun Wei, Guobin Xu, Anais Sidonia, Chris Nenopoulos, Hossam Tashkandi, Caroline Shen, Allison Wang, Alex Wang, Ke Zhang   +13 more
wiley   +1 more source

A novel in silico molecular tool for comprehensive differentiation of Mycobacterium species. [PDF]

Sci Rep
Diab MK, Soliman THA, Mohamed AM, Elsemman IE.   +3 more
europepmc   +1 more source

High‐Throughput Encapsulation of Stem Cells: Characterizing Dynamic Culture Variability With a Millifluidic Approach

Advanced Healthcare Materials, EarlyView.
A high throughput millifluidic encapsulation platform is engineered and standardized. The system's output allows the monitoring of cell expansion in strong dynamic conditions. High polymer crosslinking leads to higher cell proliferation and lower cell growth on microgel's surface.
Oscar Fabian García‐Aponte, Marta Serra, Simon Kahlenberg, Guruprakash Subbiahdoss, Erik Reimhult, Dominik Egger, Cornelia Kasper   +6 more
wiley   +1 more source

Sheep immune response against a novel recombinant enterotoxemia and infectious necrotic hepatitis vaccine in Türkiye. [PDF]

BMC Vet Res
Ekinoğlu DN, Çelik V, Gül E, Kalender H, Öngör H, Çetinkaya B.   +5 more
europepmc   +1 more source

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

Advanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan, Jonathan James Stanley Rickard, Mark Robert Thomas, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source