Results 141 to 150 of about 3,843,395 (391)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

DnaSP 6: DNA Sequence Polymorphism Analysis of Large Data Sets.

open access: yesMolecular biology and evolution, 2017
J. Rozas   +6 more
semanticscholar   +1 more source

DNA sequence reading by image processing: a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in computer science at Massey University [PDF]

open access: yes, 1993
The research described in this thesis is the development of the DNA sequence reading system. Macromolecular sequences of DNA are the encoded form of the genetic information of all living organisms.
Fan, Baozhen
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

iGenomics: Comprehensive DNA sequence analysis on your Smartphone. [PDF]

open access: yesGigascience, 2020
Palatnick A   +3 more
europepmc   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

DNA sequence analysis and Jk blood group genotype-phenotype assessment. [PDF]

open access: yesAnn Transl Med, 2020
Liang S   +7 more
europepmc   +1 more source

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