Results 41 to 50 of about 2,166,198 (276)

Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands [PDF]

, 1998
Sequence-specific DNA-binding small molecules that can permeate human cells potentially could regulate transcription of specific genes. Multiple cellular DNA-binding transcription factors are required by HIV type 1 for RNA synthesis.
Baird, Eldon E., Dervan, Peter B., Dickinson, Liliane A., Gottesfeld, Joel M., Gulizia, Richard J., Mosier, Donald E., Trauger, John W.   +6 more
core   +1 more source

Stable DNA Sequence Over Close-Ending and Pairing Sequences Constraint

Frontiers in Genetics, 2021
DNA computing is a new method based on molecular biotechnology to solve complex problems. The design of DNA sequences is a multi-objective optimization problem in DNA computing, whose objective is to obtain optimized sequences that satisfy multiple ...
Xue Li, Ziqi Wei, Bin Wang, Tao Song
doaj   +1 more source

Mapping the Space of Genomic Signatures

, 2014
We propose a computational method to measure and visualize interrelationships among any number of DNA sequences allowing, for example, the examination of hundreds or thousands of complete mitochondrial genomes.
Bryans, Nathaniel, Dattani, Nikesh S., Davis, Katelyn, Hill, Kathleen A., Karamichalis, Rallis, Kari, Lila, Sayem, Abu S.   +6 more
core   +2 more sources

Frequent Patterns Mining in DNA Sequence

IEEE Access, 2019
As a common biological sequence, DNA sequences contain important information. The discovery of frequent patterns in DNA sequences can help to study the evolution, function and variation of genes.
Na Deng, Xu Chen, Desheng Li, Caiquan Xiong   +3 more
doaj   +1 more source

Information decomposition of symbolic sequences

, 2003
We developed a non-parametric method of Information Decomposition (ID) of a content of any symbolical sequence. The method is based on the calculation of Shannon mutual information between analyzed and artificial symbolical sequences, and allows the ...
Adams, Almirantis, Audi, Benson, Benson, Chaley, Chechetkin, Cole, Conway, Coward, Dodin, Dodin, E.V. Korotkov, Fraser, Glaser, Grosse, Heringa, Herren, Hertz, Herzel, Jackson, Junker, Korotkova, Kullback, Lobzin, Lotman, M.A. Korotkova, Margot, Marple, McLachlan, N.A. Kudryashov, Ng, Pennisi, Presta, Rackovsky, Ramakrishna, Rashid, Silverman, Stoesser, Tiwari, Tomb, Trifonov, Venter, Voss, Wang, Weiss, Yaglom, Zirmunsky   +47 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Mutual information for examining correlations in DNA

, 2004
This paper examines two methods for finding whether long-range correlations exist in DNA: a fractal measure and a mutual information technique. We evaluate the performance and implications of these methods in detail.
A. ALLISON, D. ABBOTT, Dover G. A., Joset F., M. J. BERRYMAN   +4 more
core   +2 more sources

Robust signatures in the current-voltage characteristics of DNA molecules oriented between two graphene nanoribbon electrodes [PDF]

, 2012
In this work we numerically calculate the electric current through three kinds of DNA sequences (telomeric, \lambda-DNA, and p53-DNA) described by different heuristic models.
Alberts B, Berashevich J A, Carlos J Páez, Carvalho R C P, Chakraborty T, Cuniberti G, Datta S, López Sancho M P, Neil R Wilson, Peter A Schulz, Rudolf A Römer   +10 more
core   +3 more sources

Fast DNA sequencing

Medical Hypotheses, 2000
A method for fast nucleotide sequencing is described. It is based in the selection of well-known small oligomers able to be hybridized with the unknown target. The selected oligomers are afterwards ordered following a simple statistical approach. The use of capillary electrophoresis for the analysis is emphasized.
Figureau, A., Soto, M.A., Toha, J.
openaire   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source