Results 161 to 170 of about 1,195,007 (265)

From air to insight: the evolution of airborne DNA sequencing technologies. [PDF]

Microbiology (Reading)
Berelson MFG, Heavens D, Nicholson P, Clark MD, Leggett RM.   +4 more
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Nanopore-Aware Embedded Detection for Mobile DNA Sequencing: A Viterbi-HMM Design Versus Deep Learning Approaches. [PDF]

Biosensors (Basel)
Hammad K, Wu Z, Ghafar-Zadeh E, Magierowski S.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Unraveling single-molecule reactions via multiplexed in-situ DNA sequencing

Hazra JP, Andrews R, Turner P, Zhao Q, Steuer H, El-Sagheer AH, Mazumder A, El Sayyed H, Kümmerlin M, Brown T, Kapanidis AN.   +10 more
europepmc   +1 more source

SNACS: a tool for demultiplexing single-cell DNA sequencing data. [PDF]

Bioinformatics
Kennedy VE, Roy R, Peretz CAC, Koh A, Tran E, Smith CC, Olshen AB.   +6 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Massively parallel immunopeptidome by DNA sequencing provides insights into cancer antigen presentation. [PDF]

Nat Genet
Shi Q, Simon EP, Cimen Bozkus C, Kaminska A, Velazquez L, Saxena M, Zhang Z, Belk JA, Wang S, Yang N, Zhang Y, Kwong A, Che Y, Stickels RR, Crain CR, Schmidt-Hong L, Lichti CF, Gaiha GD, Roth TL, Bhardwaj N, Satpathy AT, Yu B, Chang HY.   +22 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source