Results 11 to 20 of about 1,871,571 (343)
BMC Medical Genomics, 2021 Background Coronary artery calcification (CAC) is a noninvasive measure of coronary atherosclerosis, the proximal pathophysiology underlying most cases of myocardial infarction (MI). We sought to identify expression signatures of early MI and subclinical
Xiaoling Zhang +13 more
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Circulation, 2012 We are in the midst of a time of great change in genetics that may dramatically impact human biology and medicine. The completion of the human genome project,1,2 the development of low cost, high-throughput parallel sequencing technology, and large-scale studies of genetic variation3 have provided a rich set of techniques and data for the study of ...
Frederick E, Dewey +4 more
openaire +3 more sources
BARCOSEL: a tool for selecting an optimal barcode set for high-throughput sequencing
BMC Bioinformatics, 2018 Background Current high-throughput sequencing platforms provide capacity to sequence multiple samples in parallel. Different samples are labeled by attaching a short sample specific nucleotide sequence, barcode, to each DNA molecule prior pooling them ...
Panu Somervuo +5 more
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Length-independent DNA packing into nanopore zero-mode waveguides for low-input DNA sequencing [PDF]
, 2017 Compared with conventional methods, single-molecule real-time (SMRT) DNA sequencing exhibits longer read lengths than conventional methods, less GC bias, and the ability to read DNA base modifications.
Henley, Robert Y. +4 more
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Infectious Diseases and Therapy, 2023 Introduction The introduction of pneumococcal conjugate vaccines (PCV) into the national immunization programs (NIPs) has significantly reduced the number of pneumococcal infections.
Weronika Puzia +9 more
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Exploring genome wide bisulfite sequencing for DNA methylation analysis in livestock: a technical assessment [PDF]
, 2014 peer-reviewedRecent advances made in “omics” technologies are contributing to a revolution in livestock selection and breeding practices. Epigenetic mechanisms, including DNA methylation are important determinants for the control of gene expression in ...
Couldrey, Christine, Doherty, Rachael
core +2 more sources
Ultraaccurate genome sequencing and haplotyping of single human cells. [PDF]
, 2017 Accurate detection of variants and long-range haplotypes in genomes of single human cells remains very challenging. Common approaches require extensive in vitro amplification of genomes of individual cells using DNA polymerases and high-throughput short ...
Bafna, Vineet +6 more
core +1 more source
The microbiome of the human lower airways: a next generation sequencing perspective
World Allergy Organization Journal, 2015 For a long time, the human lower airways were considered a sterile environment where the presence of microorganisms, typically revealed by culturing, was interpreted as an abnormal health state.
Velma T.E. Aho +5 more
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Case Report of COVID-19 after Full Vaccination: Viral Loads and Anti-SARS-CoV-2 Antibodies
Diagnostics, 2021 The introduction of effective vaccines against SARS-CoV-2 is expected to prevent COVID-19. However, sporadic cases of infection in vaccinated persons have been reported. We describe a case of a double-dose vaccinated woman with COVID-19.
Magdalena Komiazyk +5 more
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Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. [PDF]
, 2010 Analysis of DNA methylation patterns relies increasingly on sequencing-based profiling methods. The four most frequently used sequencing-based technologies are the bisulfite-based methods MethylC-seq and reduced representation bisulfite sequencing (RRBS),
A Bird +79 more
core +2 more sources