Results 211 to 220 of about 1,871,571 (343)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

From air to insight: the evolution of airborne DNA sequencing technologies. [PDF]

Microbiology (Reading)
Berelson MFG, Heavens D, Nicholson P, Clark MD, Leggett RM.   +4 more
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Identification of testudinis carapax and cervi cornu in Kuei-Lu-Erh-Hsien-Chiao by nested PCR and DNA sequencing methods

, 2020
K.-T. Lu, Chi-Fang Lo, Jih‐Hui Lin
openalex   +1 more source

SNACS: a tool for demultiplexing single-cell DNA sequencing data. [PDF]

Bioinformatics
Kennedy VE, Roy R, Peretz CAC, Koh A, Tran E, Smith CC, Olshen AB.   +6 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Massively parallel immunopeptidome by DNA sequencing provides insights into cancer antigen presentation. [PDF]

Nat Genet
Shi Q, Simon EP, Cimen Bozkus C, Kaminska A, Velazquez L, Saxena M, Zhang Z, Belk JA, Wang S, Yang N, Zhang Y, Kwong A, Che Y, Stickels RR, Crain CR, Schmidt-Hong L, Lichti CF, Gaiha GD, Roth TL, Bhardwaj N, Satpathy AT, Yu B, Chang HY.   +22 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

DNA Sequencing for Confirmation of Rifampin Resistance Detected by Cepheid Xpert MTB/RIF Assay [PDF]

, 2015
Allison J. McAlister, Jeffrey Driscoll, Beverly Metchock   +2 more
openalex   +1 more source

Improved circulating tumor DNA profiling by simultaneous extraction of DNA methylation and copy number information from methylated DNA sequencing data. [PDF]

NPJ Precis Oncol
Hazelaar DM, Boers RG, Boers JB, de Weerd V, Helmijr J, Phm Jansen M, Mw Verheul H, Verhoef C, Gribnau J, Martens JW, Makrodimitris S, Wilting SM.   +11 more
europepmc   +1 more source