Results 301 to 310 of about 3,677,492 (346)

DNA sequencing with nanopores

Nature Biotechnology, 2012
Major hurdles in the quest to sequence DNA with biological nanopores have now been overcome.
Grégory F Schneider, Cees Dekker
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Aligning a DNA sequence with a protein sequence

Proceedings of the first annual international conference on Computational molecular biology - RECOMB '97, 1997
We develop several algorithms for the problem of aligning DNA sequence with a protein sequence. Our methods account for frameshift errors, but not for introns in the DNA sequence. Thus, they are particularly appropriate for comparing a cDNA sequence that suffers from sequencing errors with an amino acid sequence or a protein sequence database.
Zheng Zhang, William R. Pearson, Webb Miller   +2 more
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Characteristic Sequences for DNA Primary Sequence

Journal of Chemical Information and Computer Sciences, 2002
A DNA sequence can be identified with a word over an alphabet N = [A, C, G, T]. Characteristic sequences of a DNA sequence are given in term of classifications of bases of nucleic acids. Using the characteristic sequences, we construct a set of 2 x 2 matrices to represent DNA primary sequences, which are based on counting of the frequency of occurrence
Jun Wang, Ping-an He
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A DNA sequencing strategy

Analytical Biochemistry, 1988
A modification of Lin's systematic DNA sequencing strategy is described. A method based on the religation of compatible cohesive ends generated by Sau3AI and BamHI was developed. The original procedure has been simplified and the yield of transfectant has been greatly improved.
Yu-May Lee, Sheng-Chung Lee
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Sequencing DNA bendability [PDF]

Nature Methods, 2021
Loop-seq is a high-throughput sequencing assay that measures DNA looping and can help explain how DNA bendability contributes to nucleosome organization.
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DNA Sequencing with Transposons

Journal of Computational Biology, 2000
The use of transposons offers the possibility of a directed approach to DNA sequencing, where a target DNA up to about 6kb in length can be sequenced quickly and with minimal redundancy. Transposons are mobile DNA elements which can be inserted in a reasonably random fashion into the target DNA.
Terence P. Speed, Simon Cawley
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The Future of DNA Sequencing [PDF]

Science, 1993
This article describes the emerging technologies for rapid sequencing of DNA. Technologies discussed include the use of ultrathin gels, replaceable or reusable gels, automated systems, new types of primers to replace the current shotgun method of DNA sequencing, mass spectrometric direct sequencing technologies, and sequencing by hybridization.
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Multiplex DNA Sequencing [PDF]

Science, 1988
The increasing demand for DNA sequences can be met by replacement of each DNA sample in a device with a mixture of N samples so that the normal throughput is increased by a factor of N . Such a method is described.
Stephen Kieffer-Higgins, George M. Church   +1 more
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DNA Sequencing Technology

1988
DNA sequencing is a technique that is routinely performed in many molecular biology laboratories. This paper will describe some of the advances in DNA sequencing spanning the past ten years. With current manual sequencing techniques, it is possible for an average researcher to sequence 10100,000 bases per year.
Maurice A. Kashdan, George L. Trainor
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