Results 61 to 70 of about 3,677,492 (346)

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Serotonin and tryptophan metabolites, autoantibodies and gut microbiome in APECED

Endocrine Connections, 2019
Objective: Intestinal autoimmunity with gastrointestinal (GI) dysfunction has been shown in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Emmi Naskali, Katja Dettmer, Peter J Oefner, Pedro A B Pereira, Kai Krohn, Petri Auvinen, Annamari Ranki, Nicolas Kluger   +7 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

The microbiome of the human lower airways: a next generation sequencing perspective

World Allergy Organization Journal, 2015
For a long time, the human lower airways were considered a sterile environment where the presence of microorganisms, typically revealed by culturing, was interpreted as an abnormal health state.
Velma T.E. Aho, Pedro A.B. Pereira, Tari Haahtela, Ruby Pawankar, Petri Auvinen, Kaisa Koskinen   +5 more
doaj  

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

DNA Sequencing Predicts 1st-Line Tuberculosis Drug Susceptibility Profiles

New England Journal of Medicine, 2018
BACKGROUND The World Health Organization recommends drug‐susceptibility testing of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment decisions and improve outcomes.
Caroline Irena Lijun Patrick Maryline Phelim Andrea M Irvin Allix-Béguec Arandjelovic Bi Beckert Bonnet Bradle, C. Allix-Béguec, Irena Arandjelović, L. Bi, Patrick Beckert, M. Bonnet, Phelim Bradley, A. Cabibbe, I. Cancino-Muñoz, M. Caulfield, A. Chaiprasert, D. Cirillo, D. Clifton, I. Comas, D. Crook, M. D. De Filippo, Han de Neeling, R. Diel, F. Drobniewski, K. Faksri, M. Farhat, Joy Fleming, P. Fowler, Tom Fowler, Q. Gao, J. Gardy, D. Gascoyne-Binzi, A. G. Gibertoni Cruz, A. Gil-Brusola, Tanya Golubchik, X. Gonzalo, L. Grandjean, G. He, J. Guthrie, S. Hoosdally, Martin Hunt, Z. Iqbal, N. Ismail, J. Johnston, F. Khanzada, C. Khor, T. Kohl, Clare Kong, S. Lipworth, Qingyun Liu, G. Maphalala, E. Martínez, V. Mathys, M. Merker, P. Miotto, N. Mistry, David A. J. Moore, Megan R. Murray, S. Niemann, R. Ong, T. Peto, J. Posey, T. Prammananan, A. Pym, C. Rodrigues, M. Rodrigues, T. Rodwell, G. Rossolini, Elisabeth Sánchez Padilla, M. Schito, M. Schito, Xin Shen, J. Shendure, V. Sintchenko, A. Sloutsky, E. G. Smith, M. Snyder, K. Soetaert, Angela M. Starks, P. Supply, Prapat Suriyapol, S. Tahseen, P. Tang, Y. Teo, Thuong Nguyen Thuy Thuong, G. Thwaites, E. Tortoli, S. Omar, D. van Soolingen, A. Walker, T. Walker, M. Wilcox, Daniel J. Wilson, D. Wyllie, Yang Yang, Hongtai Zhang, Yanlin Zhao, B. Zhu   +92 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer

JAMA Oncology, 2019
This cohort study investigates the use of longitudinal data from ultradeep sequencing of cell-free DNA in Danish patients with colorectal cancer.
T. Reinert, T. Henriksen, E. Christensen, Shruti Sharma, R. Salari, H. Sethi, Michael Knudsen, I. Nordentoft, Hsin-Ta Wu, Antony S. Tin, Mads Heilskov Rasmussen, Søren Vang, S. Shchegrova, Amanda Frydendahl Boll Johansen, R. Srinivasan, Z. Assaf, M. Balcioğlu, A. Olson, S. Dashner, D. Hafez, S. Navarro, Shruti Goel, M. Rabinowitz, P. Billings, S. Sigurjonsson, L. Dyrskjøt, R. Swenerton, A. Aleshin, S. Laurberg, A. Husted Madsen, A. Kannerup, K. Stribolt, Søren Palmelund Krag, L. Iversen, K. Gotschalck Sunesen, C. J. Lin, B. Zimmermann, C. Lindbjerg Andersen   +37 more
semanticscholar   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

The phylogenetic position of dicyemid mesozoans offers insights into spiralian evolution

Zoological Letters, 2017
Background Obtaining phylogenomic data for enigmatic taxa is essential to achieve a better understanding of animal evolution. Dicyemids have long fascinated biologists because of their highly simplified body organization, but their life-cycles remain ...
Tsai-Ming Lu, Miyuki Kanda, Noriyuki Satoh, Hidetaka Furuya   +3 more
doaj   +1 more source