Results 61 to 70 of about 3,728,691 (365)

FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing

Nucleic Acids Research, 2016
Allele-specific copy number analysis (ASCN) from next generation sequencing (NGS) data can greatly extend the utility of NGS beyond the identification of mutations to precisely annotate the genome for the detection of homozygous/heterozygous deletions ...
R. Shen, V. Seshan
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

The Ability of Lytic Staphylococcal Podovirus vB_SauP_phiAGO1.3 to Coexist in Equilibrium With Its Host Facilitates the Selection of Host Mutants of Attenuated Virulence but Does Not Preclude the Phage Antistaphylococcal Activity in a Nematode Infection Model

Frontiers in Microbiology, 2019
Phage vB_SauP_phiAGO1.3 (phiAGO1.3) is a polyvalent Staphylococcus lytic podovirus with a 17.6-kb genome (Gozdek et al., 2018). It can infect most of the Staphylococcus aureus human isolates of dominant clonal complexes.
Aleksandra Głowacka-Rutkowska, Agnieszka Gozdek, Joanna Empel, Jan Gawor, Karolina Żuchniewicz, Aleksandra Kozińska, Janusz Dębski, Robert Gromadka, Małgorzata Łobocka, Małgorzata Łobocka   +9 more
doaj   +1 more source

Taxonomic and chemical assessment of exceptionally abundant rock mine biofilm [PDF]

PeerJ, 2017
Background An exceptionally thick biofilm covers walls of ancient gold and arsenic Złoty Stok mine (Poland) in the apparent absence of organic sources of energy.
Karolina Tomczyk-Żak, Paweł Szczesny, Robert Gromadka, Urszula Zielenkiewicz   +3 more
doaj   +2 more sources

Comprehensive Molecular Genetic Diagnostics of Birt-Hogg-Dube Syndrome in a Russian Patient with Renal Cancer and Lung Cysts: A Case Report

Case Reports in Oncology, 2021
We report a case of Birt-Hogg-Dube syndrome (BHDS), a rare hereditary syndrome, the main visible sign of which is the development of multiple skin fibrofolliculomas.
Dmitry S. Mikhaylenko, Vsevolod B. Matveev, Margarita G. Filippova, Kirill I. Anoshkin, Nikolay A. Kozlov, Alexander V. Khachaturyan, Alexandra V. Semyanikhina, Sergey D. Nifatov, Alexander S. Tanas, Marina V. Nemtsova, Dmitry V. Zaletayev   +10 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Serotonin and tryptophan metabolites, autoantibodies and gut microbiome in APECED

Endocrine Connections, 2019
Objective: Intestinal autoimmunity with gastrointestinal (GI) dysfunction has been shown in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Emmi Naskali, Katja Dettmer, Peter J Oefner, Pedro A B Pereira, Kai Krohn, Petri Auvinen, Annamari Ranki, Nicolas Kluger   +7 more
doaj   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

DNA Sequencing Predicts 1st-Line Tuberculosis Drug Susceptibility Profiles

New England Journal of Medicine, 2018
BACKGROUND The World Health Organization recommends drug‐susceptibility testing of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment decisions and improve outcomes.
Caroline Irena Lijun Patrick Maryline Phelim Andrea M Irvin Allix-Béguec Arandjelovic Bi Beckert Bonnet Bradle, C. Allix-Béguec, Irena Arandjelović, L. Bi, Patrick Beckert, M. Bonnet, Phelim Bradley, A. Cabibbe, I. Cancino-Muñoz, M. Caulfield, A. Chaiprasert, D. Cirillo, D. Clifton, I. Comas, D. Crook, M. D. De Filippo, Han de Neeling, R. Diel, F. Drobniewski, K. Faksri, M. Farhat, Joy Fleming, P. Fowler, Tom Fowler, Q. Gao, J. Gardy, D. Gascoyne-Binzi, A. G. Gibertoni Cruz, A. Gil-Brusola, Tanya Golubchik, X. Gonzalo, L. Grandjean, G. He, J. Guthrie, S. Hoosdally, Martin Hunt, Z. Iqbal, N. Ismail, J. Johnston, F. Khanzada, C. Khor, T. Kohl, Clare Kong, S. Lipworth, Qingyun Liu, G. Maphalala, E. Martínez, V. Mathys, M. Merker, P. Miotto, N. Mistry, David A. J. Moore, Megan R. Murray, S. Niemann, R. Ong, T. Peto, J. Posey, T. Prammananan, A. Pym, C. Rodrigues, M. Rodrigues, T. Rodwell, G. Rossolini, Elisabeth Sánchez Padilla, M. Schito, M. Schito, Xin Shen, J. Shendure, V. Sintchenko, A. Sloutsky, E. G. Smith, M. Snyder, K. Soetaert, Angela M. Starks, P. Supply, Prapat Suriyapol, S. Tahseen, P. Tang, Y. Teo, T. Thuong, G. Thwaites, E. Tortoli, S. Omar, D. van Soolingen, A. Walker, T. Walker, M. Wilcox, Daniel J. Wilson, D. Wyllie, Yang Yang, Hongtai Zhang, Yanlin Zhao, B. Zhu   +92 more
semanticscholar   +1 more source