Results 81 to 90 of about 115,106 (246)

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy [PDF]

, 2013
Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents.
Alagoz, Boyd, Breslin, Caldecott, Chen, Chiang, Ciccia, Dalhus, Das, Demple, Dungey, El-Khamisy, Fu, Godon, Hecht, Hegde, Hudson, Interthal, Interthal, Kato, Katyal, Kummar, Lebedeva, Lindahl, Lindahl, Liu, Loeb, Luo, Madhusudan, Meisenberg, Meryem Alagoz, Mohammed, Morland, Murai, Murai, Nilsen, Owen S. Wells, Pommier, Pourquier, Povirk, Ray Chaudhuri, Rydberg, Sherif F. El-Khamisy, Strom, Sultana, Takashima, Wilson, Xanthoudakis, Yang, Zeng, Zhou   +50 more
core   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Structural and functional insights into the T-even type bacteriophage topoisomerase II

Nature Communications
T-even type bacteriophages are virulent phages commonly used as model organisms, playing a crucial role in understanding various biological processes. One such process involves the regulation of DNA topology during phage replication upon host infection ...
Yuhui Xin, Runqi Xian, Yunge Yang, Jingyuan Cong, Zihe Rao, Xuemei Li, Yutao Chen   +6 more
doaj   +1 more source

The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine

Haematologica, 2011
Background Topoisomerase II is essential for the maintenance of DNA integrity and the survival of proliferating cells. Topoisomerase II poisons, including etoposide and doxorubicin, inhibit enzyme-mediated DNA ligation causing the accumulation of double ...
Elisabeth J. Walsby, Steven J. Coles, Steven Knapper, Alan K. Burnett   +3 more
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Critical concepts, practice recommendations, and research perspectives of pixantrone therapy in non-Hodgkin lymphoma: a SIE, SIES, and GITMO consensus paper [PDF]

, 2016
Objectives: In this paper, we present a review of critical concepts and research perspectives and produce recommendations on the optimal use of pixantrone in non-Hodgkin lymphoma (NHL) by group discussion from an expert panel appointed by the Italian ...
Barosi, Giovanni, Corradini, Paolo, Martelli, Maurizio, Minotti, Giorgio, Oliva, Stefano, Spina, Michele, Tura, Sante, Zinzani, Pier Luigi   +7 more
core   +1 more source

A pH‐responsive charge‐reversal liposome with enhanced biofilm penetration for multimodal synergistic therapy of bacterial infections

BMEMat, EarlyView.
This study develops a pH‐responsive, charge‐reversal liposome for treating bacterial biofilm infections. With enhanced penetration capability, the liposome effectively delivers antibacterial agents into biofilms. By integrating photodynamic and photothermal therapies with antibiotics, it significantly eradicates biofilms and accelerates bacteria ...
Ruyue Li, Bo Liu, Cheng Wang, Zhencheng Sun, Shuyi Lv, Liang Tian, Minghui Xiao, Qinyang Zheng, Linqi Shi, Chunlei Zhu   +9 more
wiley   +1 more source

Effect of DNA repair deficiencies on the cytotoxicity of resveratrol [PDF]

, 2015
Numerous preclinical studies have shown that the naturally-occurring polyphenol resveratrol may produce health-beneficial effects in a variety of disorders, including cancer, diabetes, Alzheimer, and cardiovascular diseases.
Burgos Morón, Estefanía, Calderón Montaño, José Manuel, López Lázaro, Miguel, López Lázaro, Miguel (Coordinador), Mateos Cordero, Santiago, Orta Vázquez, Manuel Luis   +5 more
core  

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]

, 2014
It is well known that several antitrypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
A. Schnaufer, Agbe, Bruhn, Brun, Cristodero, Dean, Deterding, Herbert, Hoare, Holmes, Kaminsky, Lai, Lanteri, M. K. Gould, Mathis, Mukherjee, Painter, Priest, Roy Chowdhury, Räz, Schnaufer, Schnaufer, Schnaufer, Shapiro, Stuart, Tang, Thuita, Ward, Wenzler, Wenzler, Wilson, Zhang, Zuma   +32 more
core   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source