Results 91 to 100 of about 1,521,597 (298)
Haematologica, 2011 Background Topoisomerase II is essential for the maintenance of DNA integrity and the survival of proliferating cells. Topoisomerase II poisons, including etoposide and doxorubicin, inhibit enzyme-mediated DNA ligation causing the accumulation of double ...
Elisabeth J. Walsby +3 more
doaj +1 more source
The Molecular Perspective: DNA Topoisomerases [PDF]
STEM CELLS, 2002 Abstract Learning Objectives After completing this course, the reader will be able to: Gain a basic understanding of the structure and function of the DNA topoisomerases and their place as targets for chemotherapy. Access and take the CME test online and receive one
openaire +3 more sources
Structure of the N-terminal gyrase B fragment in complex with ADP⋅Pi reveals rigid-body motion induced by ATP hydrolysis [PDF]
, 2014 Type II DNA topoisomerases are essential enzymes that catalyze topological rearrangement of double-stranded DNA using the free energy generated by ATP hydrolysis.
Stanger, Frédéric V. +9 more
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Can DNA Topoisomerases Be Ribonucleases? [PDF]
Cell, 1997 DNA topoisomerases catalyze changes in the linkage of DNA strands through a concerted mechanism of DNA strand cleavage and ligation reactions (for review, seeWang 1996xWang, J.C. Annu. Rev. Biochem. 1996; 65: 635–692Crossref | PubMedSee all ReferencesWang 1996).
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Caracterização das DNA topoisomerases II de Trypanosoma rangeli [PDF]
, 2012 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia, Florianópolis, 2010DNA topoisomerases são enzimas que participam de diversos processos celulares tais como: replicação ...
Stoco, Patrícia Hermes
core
Cellular Processing Pathways Contribute to the Activation of Etoposide- Induced DNA Damage Responses
, 2009 Cytotoxic action (tumor cell killing) and carcinogenic side effect ( therapy-related secondary leukemia) of etoposide are closely related to its ability in stabilizing topoisomerase II cleavable complex (TOP2cc), a unique form of protein- linked DNA ...
FAN, JIA-RONG;PENG, AN-LIN;LO, SHU-CHI;HUANG, TING-HSIANG;LI, TSAI-KUN +1 more
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Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy
Angewandte Chemie International Edition, EarlyView.Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean +3 more
wiley +1 more source
Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells [PDF]
, 2015 We report the whole genome ChIP seq for human TOP2B from MCF7 cells. Using three different peak calling methods, regions of binding were identified in the presence or absence of the nuclear hormone estradiol, as TOP2B has been reported to play a role in ...
Catriona M. Manville +21 more
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Phosphorylation events surrounding the DNA damage response in "Saccharomyces cerevisiae" [PDF]
, 2007 Protein phosphorylation mediated by checkpoint kinases is crucial for the cellular response to DNA damage. The sensor kinases Mec1 and Tel1 initiate the checkpoint signaling cascade by directly activating the checkpoint effector kinase Rad53.
Schleker, Thomas Andreas
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Animal Research and One Health, EarlyView.Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali +10 more
wiley +1 more source