Results 111 to 120 of about 1,521,597 (298)

Investigation of the Enyzmatic Interactions Between Roxithromycin and DNA Topoisomerase I and II

Cumhuriyet Science Journal
drugs. The reasons underlying this unique priority are that topoisomerase enzymes are indispensable for the cell's own life dynamics, in the synthesis of RNA and proteins in the cell, or more importantly, for the preservation of genetic material.
Gültekin Gökçe, Pakize Cantürk, Esra Koca   +2 more
doaj   +1 more source

Independence from kinetoplast DNA maintenance and expression is associated with multi-drug resistance in Trypanosoma brucei in vitro [PDF]

, 2014
It is well known that several anti-trypanosomatid drugs accumulate in the parasite's mitochondrion, where they often bind to the organellar DNA, the kinetoplast.
Schnaufer, Achim; id_orcid, Gould, Matthew K   +1 more
core   +1 more source

Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology

Journal of the Chinese Chemical Society, EarlyView.
Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Precision medicine in cancer: A comprehensive review of advanced cancer diagnosis technologies and personalized treatment strategies

Precision Medical Sciences, EarlyView.
The translational pipeline of precision medicine in clinical oncology. Schematic overview of the individualized cancer care workflow. (1) Input: Patient samples undergo multi‐omic profiling via NGS, single‐cell diagnostics, spatial maps, and epigenetic sequencing.
Asif Jan, Bushra Waheed, Rani Akbar, Daniel Dubwa   +3 more
wiley   +1 more source

Antimicrobial Potential of Phytochemicals from Coccinia grandis Leaves: A Molecular Docking Study Against Penicillin-Binding Protein 5 of Escherichia coli and DNA Topoisomerase IV Subunit B (ParE 24kDa) of Staphylococcus aureus and Escherichia coli

Biology, Medicine & Natural Product Chemistry
Coccinia grandis (C. grandis) leaves, traditionally used in Sri Lanka for diabetes management, also have a potential antimicrobial activity. In this study, site-specific molecular docking was performed to investigate the antimicrobial activity of ...
Malshan Isuranga, Dulki Nihinsa Danthanarayana   +1 more
doaj   +1 more source

Rôle de la GTPase RhoB dans la réponse aux dommages à l'ADN induits par la camptothécine [PDF]

, 2013
RhoB est une GTPase impliquée dans diverses fonctions intracellulaires comme l'organisation du cytosquelette. En plus de ses rôles bien établis, RhoB a récemment émergé comme un gène de réponse précoce aux dommages à l'ADN.
Mamouni, Kenza
core  

Ring fusion strategy for the synthesis of anthra[2,3-d]oxazole-2-thione-5,10-dione homologues as DNA topoisomerase inhibitors and as antitumor agents

, 2017
The efficient synthesis of mono-substituted anthraquinones and ring fusion into anthra[2,3-d]oxazole-2-thione-5,10-dione derivatives were developed, and all the compounds were tested for their cytotoxicity against PC-3 cancer cell lines. Compounds 8, 14,
顧記華, Chen, Chun-Liang;Liu, Fei-Lan;Lee, Chia-Chung;Chen, Tsung-Chih;Chang, Wen-Wei;Guh, Jih-Hwa;Ali, Ahmed Atef Ahmed;Chang, Deh-Ming;Huang, Hsu-Shan   +1 more
core   +1 more source