Results 81 to 90 of about 113,306 (267)

Structural and functional insights into the T-even type bacteriophage topoisomerase II

Nature Communications
T-even type bacteriophages are virulent phages commonly used as model organisms, playing a crucial role in understanding various biological processes. One such process involves the regulation of DNA topology during phage replication upon host infection ...
Yuhui Xin, Runqi Xian, Yunge Yang, Jingyuan Cong, Zihe Rao, Xuemei Li, Yutao Chen   +6 more
doaj   +1 more source

The antimicrobial activity of exogeno us anionic phospholipids against Mycobacterium tuberculosis and Escherichia coli

Тонкие химические технологии, 2016
The effect of anionic phospholipids, namely, cardiolipin, phosphatidylglycerol and phosphatidic acid, on the growth of gram-negative bacteria E. coli BL21(DE3), as well as gram-positive bacteria M. tuberculosis H37Rv was investigated in this study.
Yu. L. Mikulovich, G. M. Sorokoumova, А. А. Selishcheva, V. I. Shvets   +3 more
doaj   +1 more source

Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures [PDF]

, 2013
DNA supercoiling is an inherent consequence of twisting DNA and is critical for regulating gene expression and DNA replication. However, DNA supercoiling at a genomic scale in human cells is uncharacterized.
A Saunders, AC Seila, AF Stewart, AS Belmont, B Schuster-Böckler, B Villeponteau, B Villeponteau, Bauke Ylstra, C Hou, C Naughton, C Naughton, Catherine Naughton, D Sproul, DS Gilmour, DS Gilmour, EP Nora, F Pedone, G Bernardi, GD Cimino, GN Giaever, H Caron, H Tabuchi, H Weintraub, I Bermúdez, Ioulia K Mati, J Filipski, James G Prendergast, JK Stock, JR Dixon, LF Liu, LJ Core, M Costantini, M Dunaway, M Ljungman, M Ljungman, M Merkenschlager, M Mizutani, M Mizutani, Mark Bradley, MC Schultz, MJ Lercher, MP Marsden, MT Tomic, MV Blagosklonny, N Gilbert, N Hay, Nick Gilbert, Nicolaos Avlonitis, P Preker, Paul P Eijk, R Métivier, R Versteeg, RD Kornberg, RK Sachs, RR Sinden, RS Joshi, S Chambeyron, Samuel Corless, Scott L Cockroft, WA Saffran, Y Hu, Y Zhou   +61 more
core   +2 more sources

The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine

Haematologica, 2011
Background Topoisomerase II is essential for the maintenance of DNA integrity and the survival of proliferating cells. Topoisomerase II poisons, including etoposide and doxorubicin, inhibit enzyme-mediated DNA ligation causing the accumulation of double ...
Elisabeth J. Walsby, Steven J. Coles, Steven Knapper, Alan K. Burnett   +3 more
doaj   +1 more source

RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals [PDF]

, 2016
DNA Topoisomerases are essential to resolve topological problems during DNA metabolism in all species. However, the prevalence and function of RNA topoisomerases remain uncertain.
Ahmad, Muzammil, Ciaramella, Maria, Debat, Hélène, Gorospe, Myriam, Hsieh, Tao-Shih, Lee, Seung Kyu, Leng, Fenfei, Li, Wen, Martindale, Jennifer L, Nadal, Marc, Niu, Hengyao, Pommier, Yves, Shen, Weiping, Siaw, Grace Ee-Lu, Tse-Dinh, Yuk-Ching, Wang, Quan, Wang, weidong, Xu, Dongyi, Xu, Yutong, Zhang, Hongliang, Zou, Sige   +20 more
core   +3 more sources

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

RNase H enables efficient repair of R-loop induced DNA damage. [PDF]

, 2016
R-loops, three-stranded structures that form when transcripts hybridize to chromosomal DNA, are potent agents of genome instability. This instability has been explained by the ability of R-loops to induce DNA damage. Here, we show that persistent R-loops
Amon, Jeremy D, Koshland, Douglas
core   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Determination of the Primary Molecular Target of 1,2,4-Triazole-Ciprofloxacin Hybrids [PDF]

, 2015
We have synthesized and examined the antibacterial activity, toxicity and affinity towards bacterial type II topoisomerases of a series of 1,2,4-triazole-ciprofloxacin hybrids.
Agata Paneth, Aleksandra Strzelczyk, Anna Malm, Barbara Kaproń, Barbara Rajtar, Dalhoff, Małgorzata Polz-Dacewicz, Oliphant, Paweł Stączek, Sharma, Tomasz Plech, Urszula Kosikowska, Łukasz Świątek   +12 more
core   +2 more sources

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source