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Coordinated control of genome-nuclear lamina interactions by topoisomerase 2B and lamin B receptor. [PDF]
Nucleic Acids Resvan Schaik T +13 more
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Journal of Medicinal Chemistry, 2017
DNA topoisomerases constitute a large family of enzymes that are essential for all domains of life. Although they share general reaction chemistry and the capacity to govern DNA topology and resolve strand entanglements during fundamental molecular processes, they are characterized by differences in their structural organization, modes of enzymatic ...
CAPRANICO, GIOVANNI +2 more
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DNA topoisomerases constitute a large family of enzymes that are essential for all domains of life. Although they share general reaction chemistry and the capacity to govern DNA topology and resolve strand entanglements during fundamental molecular processes, they are characterized by differences in their structural organization, modes of enzymatic ...
CAPRANICO, GIOVANNI +2 more
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A DNA topoisomerase type I from wheat embryo mitochondria
Plant Molecular Biology, 1986In order to study DNA replication and expression in wheat mitochondria our laboratory has been seeking to develop a system that supports DNA synthesis and transcription, either in isolated mitochondria from wheat embryos or in a mitochondrial lysate from the same source deprived of endogenous DNA in vitro.
M, Echeverria +3 more
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Stimulation of type I DNA topoisomerase gene expression by pseudorabies virus
Archives of Virology, 1997Previous results from our laboratory have demonstrated that type I DNA topoisomerase activity is required for the replication and gene expression of pseudorabies virus (PRV). In the present report, we further analyzed the expression of topoisomerase I in PRV-infected cells, and the western blot result showed that the expression of topoisomerase I was ...
M L, Wong +4 more
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Biochemical basis for the interactions of type I and type II topoisomerases with DNA
Pharmacology & Therapeutics, 1989DNA topoisomerases are complex and unique enzymes which alter the topological state of DNA without changing its chemical structure. Between the type I and II enzymes, topoisomerases carry out a multitude of reactions, including DNA binding, site specific DNA cleavage/religation, relaxation, catenation/decatenation, and knotting/unknotting of nucleic ...
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Purification and characterization of a type I DNA topoisomerase from calf thymus mitochondria
Biochemistry, 1987A type I topoisomerase has been purified more than 4000-fold from calf thymus mitochondria. The enzyme is membrane associated and is effectively solubilized by 1% Triton X-100 treatment of purified mitochondrial inner membranes. This ATP-independent enzyme relaxes positively and negatively supercoiled DNA with delta LK = 1.
G M, Lazarus +4 more
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Type II DNA Topoisomerase from Saccharomyces cerevisiae Is a Stable Dimer
Biochemistry, 1997Type II DNA topoisomerases function as homodimeric enzymes in transiently cleaving double-stranded DNA to catalyze unlinking and unknotting reactions. The dimeric enzyme creates a DNA double-strand break by forming a covalent attachment between an active site tyrosine from each monomer and a 5'-phosphate from each strand of DNA.
R B, Tennyson, J E, Lindsley
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Role of DNA topoisomerase I in the replication of herpes simplex virus type 2
Archives of Virology, 1990Camptothecin (CPT), a specific inhibitor of DNA topoisomerase I, effectively inhibited the replication of herpes simplex virus type 2 (HSV-2). CPT was found to reduce the level of immediate early viral mRNA in a dose-response manner. On the other hand, we could not find any evidence that a novel DNA topoisomerase I was induced in HSV-2-infected cells ...
Y, Yamada +3 more
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Diospyrin, A Bisnaphthoquinone: A Novel Inhibitor of Type I DNA Topoisomerase of Leishmania donovani
Molecular Pharmacology, 1998Diospyrin is a plant product that has significant inhibitory effect on the growth of Leishmania donovani promastigotes. This compound inhibits the catalytic activity of DNA topoisomerase I of the parasite. Like camptothecin, it induces topoisomerase I mediated DNA cleavage in vitro. Treatment of DNA with diospyrin before addition of topoisomerase I has
S, Ray +4 more
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1981
Publisher Summary DNA topoisomerases are enzymes that catalyze the breakage and rejoining of DNA strands. The breakage of a DNA backbone bond by a topoisomerase is followed efficiently by the rejoining of the same bond. Therefore, the disjoined state is a transient one and each cycle of breakage and rejoining of a bond is almost invariably detected ...
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Publisher Summary DNA topoisomerases are enzymes that catalyze the breakage and rejoining of DNA strands. The breakage of a DNA backbone bond by a topoisomerase is followed efficiently by the rejoining of the same bond. Therefore, the disjoined state is a transient one and each cycle of breakage and rejoining of a bond is almost invariably detected ...
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