Results 161 to 170 of about 17,370 (252)

Molecular dynamics simulations reveal DNA gate opening mechanisms for M. smegmatis topoisomerase 1A. [PDF]

Biophys J
Sigdel D, Mills M.
europepmc   +1 more source

Analytical Validation of an Annotation Tool for WGS‐Based Pharmacogenomics: Preparing for Clinical Implementation in Pediatric Oncology

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
Selection and validation of a whole genome sequencing pharmacogenomics annotation tool. ABSTRACT Whole genome sequencing (WGS) is increasingly accessible in clinical practice, enabling pharmacogenomics (PGx) integration, including in pediatric oncology.
Meta H. M. Diekstra, Nienke Biesot, Julie Donders, Eugène T. P. Verwiel, Alex Janse, Alwin D. R. Huitema, Lidwien M. Hanff, Bastiaan B. J. Tops, Patrick Kemmeren, Jayne Y. Hehir‐Kwa   +9 more
wiley   +1 more source

Topoisomerases regulate alternative transcription start site selection in yeast. [PDF]

G3 (Bethesda)
Elgood Hunt E, Vivori C, Albihlal WS, van Werven FJ.   +3 more
europepmc   +1 more source

Disproportionality Analysis of Fluoroquinolone‐Associated Peripheral Neuropathy in the FAERS Database (2007–2024)

Clinical and Translational Science, Volume 19, Issue 4, April 2026.
ABSTRACT Fluoroquinolones (FQs) are among the most frequently prescribed antibiotic classes worldwide. Despite their therapeutic versatility in treating bacterial infections, regulatory authorities recognized risks of persistent and potentially irreversible adverse effects, particularly peripheral neuropathy (PN).
Nimra Shamim, Kelly Doughty, Hau‐Tak Chau, James Brown, Robert Baldock, Ngan Pan Bennett Au   +5 more
wiley   +1 more source

Direct trapping of the transport-segment DNA by the central domain of type IIA topoisomerases. [PDF]

Sci Adv
Xin Y, Xian R, Liu C, Zhang O, Rao Z, Li X, Chen Y.   +6 more
europepmc   +1 more source

Divergent Selection on Dispersal Targets Chemosensory and Neuronal Genes in Tribolium castaneum

Molecular Ecology, Volume 35, Issue 8, April 2026.
ABSTRACT Dispersal is key to the life history, ecology and evolution of many organisms and important in pest invasiveness. However, the genetic architecture underlying variation in dispersal behaviour remains poorly understood outside of a few model species.
Michael D. Pointer, Will J. Nash, Lewis G. Spurgin, Mark McMullan, Simon Butler, David S. Richardson   +5 more
wiley   +1 more source

Supercoiled DNA recognition and cleavage control in topoisomerase VI. [PDF]

Nat Commun
Richman DE, Wendorff TJ, Rashid F, Beck C, Yan Q, Johnson HR, Eckerty RA, Fogg JM, Baker ML, Zechiedrich L, Berger JM.   +10 more
europepmc   +1 more source

Processing of DNA Topoisomerase II-DNA-Protein Crosslinks Associated With Anticancer Drugs. [PDF]

Genes Cells
Sakasai R, Iwabuchi K.
europepmc   +1 more source

Characterization of a prokaryotic topoisomerase I activity in chloroplast extracts of maize [PDF]

, 1983
Siedlecki, Janusz, Weissbach, Arthur, Zimmermann, Wolfgang   +2 more
core  

DNA Structural Features That Lead to Strand Breakage by Eukaryotic Type-I Topoisomerase

Cold Spring Harbor Symposia on Quantitative Biology, 1984
J J, Champoux, W K, McCoubrey, M D, Been
openaire   +2 more sources