Results 71 to 80 of about 17,370 (252)
Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy
Advanced Science, EarlyView.This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan +16 morewiley +1 more sourceMechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy
Advanced Science, EarlyView.A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...Murali Mohana Rao Singuru, Priyanka Bhattacharyya, Mingxu You +2 morewiley +1 more sourceLucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding.
PLoS ONE, 2011 Lucanthone and hycanthone are thioxanthenone DNA intercalators used in the 1980s as antitumor agents. Lucanthone is in Phase I clinical trial, whereas hycanthone was pulled out of Phase II trials.Mamta D Naidu, Rakhi Agarwal, Louis A Pena, Luis Cunha, Mihaly Mezei, Min Shen, David M Wilson, Yuan Liu, Zina Sanchez, Pankaj Chaudhary, Samuel H Wilson, Michael J Waring +11 moredoaj +1 more sourceMutations in topoisomerase IIβ result in a B cell immunodeficiency. [PDF]
, 2019 B cell development is a highly regulated process involving multiple differentiation steps, yet many details regarding this pathway remain unknown. Sequencing of patients with B cell-restricted immunodeficiency reveals autosomal dominant mutations in ...Austin, Caroline A, Booshehri, Laela M, Broderick, Lori, Brydges, Susannah D, Cowell, Ian G, Croker, Ben A, Frazer, Kelly A, Gebauer, Corinna, Guaderrama, Marisela, Hakonarson, Hakon, Harr, Margaret, Hoffman, Hal M, Hügle, Boris, Kucharova, Karolina, Li, Dong, McGeough, Matthew D, Patel, Niraj C, Putnam, Christopher D, Wang, Jian, Xu, Xun, Yost, Shawn, Zackai, Elaine, Zhang, Jianguo +22 morecore Single-molecule experiments in biological physics: methods and
applications
, 2006 I review single-molecule experiments (SME) in biological physics. Recent
technological developments have provided the tools to design and build
scientific instruments of high enough sensitivity and precision to manipulate
and visualize individual ..., , , , , Adachi K, Adelman K, Ahsan A, Alberts B, Allahverdyan A, Allemand J F, Altan-Bonnet G, Ashkin A, Ashkin A, Ashkin A, Ashkin A, Ashkin A, Ashkin A, Astumian R D, Astumian R D, Baumann C G, Baumann C G, Bell G I, Bennett C H, Bennink M L, Bennink M L, Bensimon D, Best R B, Bhasin N, Bhattacharjee S M, Bhattacharjee S M, Binnig G, Binnig G, Blanchard S C, Blickle V, Block S M, Block S M, Bloomfield V A, Bochkov G N, Bockelmann U, Boroudjerdi H, Bouchiat C, Braslavsky I, Brower-Toland B D, Brujic J, Bryant Z, Bundschuh R, Burgess S A, Bustamante C, Bustamante C, Bustamante C, Bustamante C, Calladine C R, Carl P, Carrion-Vazquez M, Carrion-Vazquez M, Carrion-Vazquez M, Carter N J, Carter N J, Causo M S, Charvin G, Chatenay D, Chen S-J, Ciliberto S, Clausen-Schaumann H, Cluzel P, Cocco S, Cocco S, Cocco S, Cocco S, Cocco S, Cohen E G D, Cohen E G D, Cohen E G D, Crooks G E, Crooks G E, Cross R A, Cuesta-Lopez S, Cui Y, Cui Y, Cule D, Czajkowsky D M, Córdova N J, Daban J R, Dammer U, Dammer U, Danilowicz C, Davenport R J, De Duve C, Dekker N H, Deng H, Discher D E, Dohoney K M, Douarche F, Eisenberg E, Engel A, Essevaz-Roulet B, Evans D J, Evans E, Evans E, Evans E, Evans E, Evans E, F Ritort, Fain B, Fernandez J M, Fernandez J M, Fernandez J M, Finer J T, Finkelstein A V, Finzi L, Fisher M E, Florin E L, Flyvbjerg H, Forde N R, Forkey J N, Frank-Kamentskii M D, Frechet J M, Fritz J, Fréchet J M J, Gallavotti G, Garces-Chavez V, Garcia-Manyes S, Gelles J, Gelles J, Gelles J, Gergely C, Gerland U, Gerland U, Gerland U, Gestland R F, Goel A, Goel A, Gordon M P, Gore J, Gore J, Gosse C, Grange W, Green N H, Grier D G, Gross D H E, Ha T, Ha T, Hafner J H, Hanggi P, Hanke A, Hanley W, Hansen J C, Haran G, Harlepp S, Herschlag D, Higgs P G, Hill T L, Hill T L, Hinterdorfer P, Howard J, Hummer G, Hummer G, Hwa T, Hyeon C, Inoue A, Isralewitz B, Jarzynski C, Jarzynski C, Jarzynski C, Jarzynski C, Jensen M O, Jeruzalmi D, Junier I Ritort F, Jülicher F, Kafri Y, Katritch V, Kawakami M, Keller D, Keller D, Kellermayer M S K, Kellermayer M S, Kim H D, Kindt J, Kitamura K, Klimov D K, Klug A, Konrad M W, Kosikov K M, Kosztin I, Kramers H A, Kukowska-Latallo J F, Kunze K-K, Kurchan J, Kühner F, Ladoux B, Lang M J, Lang M J, Law R, Lebowitz J L, Lebrun A, Lee G U, Lee G U, Leger J F, Leuba S H, Leuva S H, Lhua R C, Li P T X Bustamante C Tinoco I, Liphardt J, Liu F, Lu H, Léger J F, Maes C, Maes C, Maier B, Manosas M, Manosas M Wen J D Li P T X Smith S B Bustamante C Tinoco I Ritort F, Marko J, Marko J, Marko J F, Marszalek P E, Marszalek P E, Marszalek P E, Masaike T, Mathews D H, Mazonka O Jarzynski C, McGurn A R, Merkel R, Min W, Moffitt J R, Molloy J E, Moy V T, Muller D J, Munoz V, Müller D J, Müller M, Müller M, Nayashima M, Nelson D R, Nguyen T T Grossberg A Y Shklovskii B I Holm C Kekicheff P Podgornik R, Noji H, Noy A, Oberhauser A F, Onoa B, Onoa B, Onuchic J N, Oono Y, Orland H, Orlandini E, Orphanides G, Paci E, Pagnani A, Pan J, Pant K, Park S, Pauling L, Perret E, Peyrard M, Phillips W D, Poirier M G, Poland D, Poland D, Purohit P K, Qian H, Qu X, Rief M, Rief M, Rief M, Rief M, Rief M, Rief M, Ritort F, Ritort F, Ritort F, Ritort F, Ros R, Rouzina I, Rouzina I, Rubinstein M, Saleh O A, Sarkar A, Schiessel H, Schiessel H, Schlierf M, Schroeder R, Schumakovitch I, Schurr J M, Schwesinger F, Seifert U, Sellers J R, Shaevitz J W, Smith B L, Smith D E, Smith S B, Soong R K, Sosnick T R, Speck T, Spudich A, Strick T, Strick T R, Strick T R, Strick T R, Strunz T, Svoboda K, Tanaka H, Thirumalai D, Thurmond K B, Tinoco I, Tinoco I, Tinoco I, Tinoco I, Tinoco I, Treiber D K, Treiber D K, Trepagnier E H, Tsallis C, Uemura S, Uptain S M, Valpuesta J M, Vanzi F, Veigel C, Veigel C, Visscher K, Vologodskii A, Wang M D, Wang M D, Wartell R M, Watson J D, Watson J D, Wen J D Manosas M Li P T X Smith S B Bustamante C Ritort F Tinoco I, Wenner J R, Widom J, Wiita A P, Wilkins M H F, Williams M C, Williams M C, Williams M C, Williams P M, Williams P M, Wood R H, Woodcock C L, Wuite G J L, Xie Z, Yager T D, Yang G, Yasuda R, Yasuda R, Yildiz A, Yildiz A, Yin H, Zandi R, Zarrinkar P, Zhou H, Zhuang X, Zuckermann D M, Zuker M, Zwanzig R W +351 morecore +1 more sourceIdentification and characterization of the orf virus type I topoisomerase [PDF]
, 1995 Vaccinia virus (VV) and Shope fibroma virus (SFV), representatives of the orthopox and leporipox genera, respectively,encode type I DNA topoisomerases.Nancy Klemperer, David J. Lyttle, Dominique Tauzin, Paula Traktman, Anthony J. Robinson, Bauer, Brill, Champoux, D'Arpa, DeLange, Fernandez-Beros, Fleming, Fleming, Fogelsong, Fraser, Goebel, Gupta, Higgins, Kim, Klemperer, Laemmu, Liu, Lynn, Mercer, Moore, Morham, Morham, Moss, Osheroff, Rigby, Rosel, Sanger, Schultz, Shaffer, Shuman, Shuman, Shuman, Shuman, Shuman, Shuman, Shuman, Shuman, Studier, Thrash, Traktman, Traktman, Traktman, Uemura, Upton, Vogelstein, Wang, Wang +51 morecore +5 more sourcesThe Effect of Dimethyl Sulfoxide on Supercoiled DNA Relaxation Catalyzed by Type I Topoisomerases [PDF]
BioMed Research International, 2015 The effects of dimethyl sulfoxide (DMSO) on supercoiled plasmid DNA relaxation catalyzed by two typical type I topoisomerases were investigated in our studies. It is shown that DMSO in a low concentration (less than 20%, v/v) can induce a dose-related enhancement of the relaxation efficiency ofEscherichia colitopoisomerase I (type IA).Lv, Bei, Dai, Yunjia, Liu, Ju, Zhuge, Qiang, Li, Dawei +4 moreopenaire +3 more sourcesPhotodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo
Advanced Science, EarlyView.Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan +7 morewiley +1 more sourceReconstitution and functional characterization of the unusual bi‐subunit type I DNA topoisomerase from Leishmania donovani [PDF]
FEBS Letters, 2004 Leishmania donovani topoisomerase I is an unusual bi‐subunit enzyme. The activity of the enzyme has been detected when the genes of the individual subunits were co‐expressed in yeast [J. Biol. Chem. 278 (2003) 3521]. Here, we report for the first time, the in vitro reconstitution of the two recombinant proteins, LdTOP1L and LdTOP1S, corresponding to ...Brata Das, Benu, Sen, Nilkantha, Ganguly, Agneyo, Majumder, Hemanta K. +3 moreopenaire +2 more sources
