Results 81 to 90 of about 17,370 (252)

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Unzipping DNA - towards the first step of replication

, 1999
The opening of the Y-fork - the first step of DNA replication - is shown to be a critical phenomenon under an external force at one of its ends. From the results of an equivalent delocalization in a non-hermitian quantum-mechanics problem we show the ...
Bhattacharjee, Somendra M.
core   +1 more source

Over-expression of Topoisomerase II Enhances Salt Stress Tolerance in Tobacco [PDF]

, 2016
Topoisomerases are unique enzymes having an ability to remove or add DNA supercoils and untangle the snarled DNA. They can cut, shuffle and religate DNA strands and remove the torsional stress during DNA replication, transcription or recombination events.
Badri N. Singh, Malireddy K. Reddy, Manchikatla V. Rajam, Riffat John, Sudhir K. Sopory, Tanushri Kaul, Uma Ganeshan   +6 more
core   +2 more sources

Improvement and Replacement of Camptothecins in Cancer Therapy Due to the Decrease in their Selectivity and Efficiency [PDF]

, 2005
DNA replication, transcription, and chromosome condensation require enzymes that can regulate the topological changes occurring in DNA following these processes. Topoisomerases are such enzymes. These catalyze the cleavage of single-stranded DNA (ssDNA)
Kilian, Dorota
core   +1 more source

What is the length of a knot in a polymer?

, 2005
We give statistical definitions of the length, l, of a loose prime knot tied into a long, fluctuating ring macromolecule. Monte Carlo results for the equilibrium, good solvent regime show that ~ N^t, where N is the ring length and t ~ 0.75 is ...
Marcone, B., Orlandini, E., Stella, A. L., Zonta, F.   +3 more
core   +1 more source

A two-subunit type I DNA topoisomerase (reverse gyrase) from an extreme hyperthermophile. [PDF]

Proceedings of the National Academy of Sciences, 1996
A recently described reverse gyrase from the hyperthermophilic methanogen Methanopyrus kandleri is the only known example of a heterodimeric type I topoisomerase. The enzyme is made up of a 42-kDa subunit which covalently interacts with DNA (RgyA) and a 138-kDa subunit which binds ATP (RgyB). We have now cloned and sequenced the genes for both subunits
R, Krah, S A, Kozyavkin, A I, Slesarev, M, Gellert   +3 more
openaire   +2 more sources

Insights from the Structure of Mycobacterium tuberculosis Topoisomerase I with a novel protein fold [PDF]

, 2016
The DNA topoisomerase I enzyme of Mycobacterium tuberculosis (MtTOP1) is essential for the viability of the organism and survival in a murine model. This topoisomerase is being pursued as a novel target for the discovery of new therapeutic agents for the
Cao, Nan, Cheng, Bokun, Joachimiak, Andrezej, Tan, Kemin, Tse-Dinh, Yuk-Ching   +4 more
core   +2 more sources

Topoisomerase III, but not topoisomerase I, can support nascent chain elongation during theta-type DNA replication.

Journal of Biological Chemistry, 1994
Topoisomerase III, but not topoisomerase I, could, in the absence of DNA gyrase, support bidirectional DNA replication in an oriC plasmid DNA replication system reconstituted with purified proteins. The initial rate of DNA synthesis and the efficiency of nascent chain elongation showed that topoisomerase III-stimulated DNA replication was as efficient ...
H, Hiasa, K J, Marians
openaire   +2 more sources

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Knotting probabilities after a local strand passage in unknotted self-avoiding polygons

, 2011
We investigate the knotting probability after a local strand passage is performed in an unknotted self-avoiding polygon on the simple cubic lattice.
Bates A, Berg B, Berger J M, Berretti A, Buck G, Burnier Y, C E Soteros, Clisby N, de Carvalho C A, de Carvalho C A, Fishman G S, Fogg J M, Gelman A, Gelman A, Guttmann A J, Hua X, Janse van Rensburg E J, Janse van Rensburg E J, Janse van Rensburg E J, Janse van Rensburg E J, Liu Z, Liu Z, Liu Z, Liu Z R, M L Szafron, Manturov V, Marcone B, Orlandini E, Orlandini E, Orlandini E, Rybenkov V V, Shaw S Y, Sokal A D, Sumners D W, Szafron M L, Szafron M L, Trigueros S, Vologodskii A, Yan J   +38 more
core   +1 more source