Results 91 to 100 of about 17,370 (252)
Fluorescently labeled circular DNA molecules for DNA topology and topoisomerases [PDF]
, 2016 DNA topology plays essential roles in several fundamental biological processes, such as DNA replication, recombination, and transcription. Typically agarose gel electrophoresis is employed to study DNA topology.
Berrido, Andrea +5 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
wiley +1 more source
Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate. [PDF]
, 2018 Type IIA topoisomerases (Top2s) manipulate the handedness of DNA crossovers by introducing a transient and protein-linked double-strand break in one DNA duplex, termed the DNA-gate, whose opening allows another DNA segment to be transported through to ...
Chan, Nei-Li +7 more
core +2 more sources
Macromolecular Rapid Communications, EarlyView.Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley +1 more source
CrystalsType II topoisomerases (TOP2s) play a key role in altering the DNA topology by transiently cleaving both strands of a DNA duplex. Therefore, increased TOP2 activity is associated with many cancers.
Martina I. Peeva +8 more
doaj +1 more source
mLife, EarlyView.Abstract Bacterial persisters show tolerance to bactericidal antibiotics and play essential roles in chronic infections; however, the general mechanisms underlying persister formation and antibiotic tolerance remain insufficiently characterized. In this study, the Escherichia coli Keio library was used to identify genes involved in ciprofloxacin ...
Zhenfang Mei +9 more
wiley +1 more source
Supercoiled DNA: Structure [PDF]
, 2015 Supercoiling is introduced into DNA molecules when the double helix is twisted around its own axis in three‐dimensional space. Experimental techniques that are sensitive to molecular shape can be used to analyse the topological states of DNA, but the ...
Bowater, Richard
core +1 more source
Recent advances in noncanonical inhibition mechanisms of anti‐CRISPR proteins
mLife, EarlyView.Abstract The CRISPR‐Cas system constitutes an adaptive immune mechanism in prokaryotes that defends against mobile genetic elements. Within the perpetual co‐evolutionary arms race between bacteria and their viral predators, bacteriophages encode anti‐CRISPR (Acr) proteins that use sophisticated molecular strategies to sabotage CRISPR‐Cas function ...
Lingguang Yang +5 more
wiley +1 more source
Effects of camptothecin derivatives and topoisomerase dual inhibitors on Trypanosoma cruzi growth and ultrastructure [PDF]
, 2014 BACKGROUND: Trypanosoma cruzi is the etiological agent of Chagas’ disease that is an endemic disease in Latin America and affects about 8 million people.
Aline Araujo Zuma +4 more
core +1 more source
Phytochemical Analysis, EarlyView.ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek +3 more
wiley +1 more source