Results 121 to 130 of about 9,967 (240)

A living biobank of sarcoma patient‐derived cell cultures reveals multi‐omic and functional insights that capture disease heterogeneity

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Preclinical models for sarcoma that preserve tumour biology are urgently needed to advance mechanistic understanding and functional precision oncology. 29 early‐passage patient‐derived sarcoma cell (PDC) cultures from 19 patients, representing 11 sarcoma subtypes were established and extensively characterized.
Stefanie Gijsels, Suzanne Fischer, David Creytens, Sándor Dedeyne, Felix De Vuyst, Cláudio Pinheiro, Fleur Cordier, Sarah‐Lee Bekaert, Nadine Van Roy, Kaat Durinck, Jarne Pauwels, Kris Gevaert, Pieter Mestdagh, Jo Vandesompele, Pekka Rappu, Jyrki Heino, An Hendrix, Gabrielle H. van Ramshorst, Gwen Sys, Olivier De Wever   +19 more
wiley   +1 more source

Exosome Secretion Drives Chemo‐Resistance of Temozolomide in Glioblastoma

Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.
ABSTRACT Temozolomide (TMZ) is a first‐line chemotherapeutic agent for the treatment of glioblastoma (GBM), while a majority of patients do not effectively respond to TMZ owing to the multiple resistance mechanisms. In this study, we found that TMZ treatment substantially increased the exosome secretion from GBM cell line.
Wenpei Li, Shaoping Jiang, Kun Liu, Zhi Li, Jun Yang, Weimin Liu, Yuanyu Huang, Minghui Yang, Shuai Guo, Shaobo Ruan   +9 more
wiley   +1 more source

Conformational Coordination of Strand Passage by Type IIA and Type IIB Topoisomerases [PDF]

, 2017
Topoisomerases are essential molecular machines that manage physical challenges presented by DNA topology. Life has evolved two classes of enzyme, type IIA and type IIB topoisomerases, which unlink entangled chromosomes by coordinating a complex, ATP ...
Wendorff, Timothy John
core  

Inhibitory action of exogenous cardiolipin on the bacterial type i and ii dna topoisomerases in vitro

Тонкие химические технологии, 2012
The influence of empty liposomes composed of cardiolipin (lipid which is a component of the bacterial cytoplasmic membrane and eukaryotic internal mitochondrial membrane) on Escherichia coli topoisomerase I and DNA gyrase (topoisomerase II) in vitro was ...
Yu. L. Mikulovich, G. М. Sorokoumova, А. А. Selishcheva, V. I. Shvets   +3 more
doaj  

Antibiotics in Veterinary Ophthalmology: Resistance, Stewardship, and Emerging Antibiotic‐Sparing Strategies

Veterinary Ophthalmology, Volume 29, Issue 4, July 2026.
ABSTRACT Antimicrobial resistance (AMR) is a growing challenge in veterinary ophthalmology, particularly in cases of bacterial keratitis, where progressive stromal infection can threaten vision and globe integrity within hours to days. This review synthesizes current evidence on pathogen distribution, antimicrobial susceptibility profiles, multidrug ...
Lionel Sebbag, Oren Pe'er
wiley   +1 more source

Optimisation of a Novel Class of DNA Gyrase Inhibitors to Improve Antibacterial Activity

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
This article describes efforts to increase the antibacterial activity of a recently reported class of novel DNA gyrase inhibitors known as the isoquinoline sulphonamides by improving their uptake in bacterial cells. As antibiotic resistance continues to rise, the need for new antibacterials is clear.
Meg I. Ferguson, Cerissa C. van Walstijn, Vladyslav Lysenko, Marta A. Wilbrink, David Alencar Araripe, Jeroen M. Punt, Mario van der Stelt, Willem Jespers, Paolo Innocenti, Nathaniel I. Martin   +9 more
wiley   +1 more source

Studies on Type I and Type II DNA Topoisomerases From Mammalian Mitochondria

, 1993
Mammalian mitochondria contain a unique DNA topoisomerase I with characteristics of both nuclear and bacterial type I DNA topoisomerases. This enzyme, purified from bovine liver, requires cations as cofactors and possesses optimal activity at pH 7.0, 37 ...
LIn, Jia-Hwei
core   +1 more source

The DNA Cleavage Reaction of Human Type II Topoisomerases

, 2009
The work presented in this dissertation examines the DNA cleavage activity of human topoisomerase II. Type II topoisomerases are required for removing DNA knots and tangles and are important chemotherapy drug targets.
Deweese, Joseph Edward
core  

Structural insight into the quinolone–DNA cleavage complex of type IIA topoisomerases

, 2009
Type II topoisomerases alter DNA topology by forming a covalent DNA-cleavage complex that allows DNA transport through a double-stranded DNA break. We present the structures of cleavage complexes formed by the Streptococcus pneumoniae ParC breakage ...
Andrew W Thompson, Pan, Xiao-Su, L Mark Fisher, Xiao-Su Pan, Mark R Sanderson, Fisher, L. Mark, Katherine E McAuley, Sanderson, Mark R., Thompson, Andrew W., Laponogov, Ivan, Dennis A Veselkov, Ritica Sawhney, McAuley, Katherine E., Maninder K Sohi, Veselkov, Dennis A., Ivan Laponogov, Sawhney, Ritica, Sohi, Maninder K.   +17 more
core   +1 more source

An interbacterial cysteine protease toxin inhibits cell growth by targeting type II DNA topoisomerases GyrB and ParE.

PLoS Biology
Bacteria deploy a diverse arsenal of toxic effectors to antagonize competitors, profoundly influencing the composition of microbial communities. Previous studies have identified an interbacterial toxin predicted to exhibit proteolytic activity that is ...
Pin-Yi Song, Chia-En Tsai, Yung-Chih Chen, Yu-Wen Huang, Po-Pang Chen, Tzu-Haw Wang, Chao-Yuan Hu, Po-Yin Chen, Chuan Ku, Kuo-Chiang Hsia, See-Yeun Ting   +10 more
doaj   +1 more source