Results 131 to 140 of about 9,967 (240)

Effects of DNA Geometry and Topoisomerase II Poisons on Human and Bacterial Type II Topoisomerases

, 2017
The topological state of DNA has a dramatic effect on nucleic acid processes in cells. Type II topoisomerases are necessary enzymes that help regulate the topological state of the genome, but their activity requires the creation of transient DNA breaks ...
Ashley, Rachel Erin
core  

Drug-Induced Conformational Population Shifts in Topoisomerase-DNA Ternary Complexes

, 2017
Type II topoisomerases (TOP2) are enzymes that resolve the topological problems during DNA replication and transcription by transiently cleaving both strands and forming a cleavage complex with the DNA.
Huang, Nan-Lan;Lin, Jung-Hsin, 林榮信
core   +1 more source

DNA Topoisomerases as Promising Targets for Leishmania Chemotherapy

, 2017
DNA topoisomerases (Top) have been identified as promising targets for therapeutic intervention in leishmaniasis. Leishmania parasites have a complete set of six classes of Top enzymes that operate in solving topological problems generated during DNA ...
Rosa M Reguera, Bárbara Domínguez-Asenjo, Camino Gutiérrez-Corbo, Rafael Balaña-Fouce, José M. Escudero-Martínez   +4 more
core   +1 more source

Genomic and Phenotypic Characterization of Streptomyces marxii sp. nov., Producer of Kinanthraquinone B

Microorganisms
Describing novel microbial species opens access to uncharted biosynthetic gene clusters and their associated secondary metabolites, offering fresh opportunities in the search for new antibiotics urgently needed to combat multidrug resistance.
Mikhail Yu. Dobryakov, Julia A. Buyuklyan, Mikhail V. Biryukov   +2 more
doaj   +1 more source

A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents

, 2019
Type II topoisomerases catalyze essential DNA transactions and are proven drug targets. Drug discrimination by prokaryotic and eukaryotic topoisomerases is vital to therapeutic utility, but is poorly understood. We developed a next-generation sequencing (
Blower, T.R., Berger, J.M., Austin, C.A., Bandak, A., Lee, A.S.Y., Nitiss, J.L.   +5 more
core   +1 more source

Rezatapopt and the Return of Targetable p53

MedComm, Volume 7, Issue 7, July 2026.
Yuanze Luo, Assam El‐Osta
wiley   +1 more source

Control of Strand Scission by Type IIA Topoisomerases [PDF]

, 2012
Topoisomerases are a family of essential enzymes that disentangle chromosomes and manage DNA supercoils, and are targets of a broad class of successful antibiotics and anticancer therapeutics.
Schmidt, Bryan Harris
core  

Characterization of Alternaria alternata alternariol monomethyl ether with a potential antiproliferative activity by topoisomerases inhibition; molecular docking and dynamic simulations. [PDF]

Sci Rep
El-Sayed ASA, Aboelez MO, Ezelarab HAA, Ewedah TM, El-Baz AF, Ashraf R, Diab A, Safwat G, Rady AM, El-Mekkawy RM.   +9 more
europepmc   +1 more source

Evolutionary Analyses of DNA Topoisomerases II and IA

, 2007
DNA strand scission and topology changes are catalyzed by DNA topoisomerases. Previous studies suggest that Type IIB topoisomerase evolved from Type IIA by gene duplication, recombination and absence.
REN, Yong-ming, TANG, Su-ni
core  

Topoisomerase inhibitors in cervical cancer: mechanistic insights and therapeutic strategies. [PDF]

Mol Med
Reddy Y, Pai P, Das I, Nayak S, D'Souza NV, Shetty MG, Sundara BK.   +6 more
europepmc   +1 more source