Results 111 to 120 of about 1,464,924 (278)

DNA topoisomerases: Advances in understanding of cellular roles and multi-protein complexes via structure-function analysis. [PDF]

Bioessays, 2021
McKie SJ, Neuman KC, Maxwell A.
europepmc   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Plant DNA Topoisomerases: Structure, Function, and Cellular Roles in Plant Development

, 2004
Regulation of the topological state of DNA is critical for cellular viability. DNA topoisomerases alter DNA topology and participate in nearly all events related to DNA metabolism such as replication, transcription, recombination, and chromosome ...
S. K. Sopory, Reddy, M. K., B. N. Singh, M. K. Reddy, Sopory, S. K., Singh, B. N.   +5 more
core   +1 more source

Two type I topoisomerases maintain DNA topology in human mitochondria [PDF]

Genetic processes require the activity of multiple topoisomerases, essential enzymes that remove topological tension and intermolecular linkages in DNA. We have investigated the subcellular localisation and activity of the six human topoisomerases with a
Rodríguez-Luis A, Deen D, Di Leo V, Austin CA, Cowell IG, Díaz-Maldonado H, Nicholls TJ, Casement JW, Menger KE, Chapman J, Erdinc D, Pyle A, Falkenberg M, Khazeem MM   +13 more
core   +4 more sources

Synergistic effects and clinical utilization of radioimmunotherapy for brain metastases from driver mutation‐negative non‐small cell lung cancer

Precision Radiation Oncology, EarlyView.
This review summarizes how combining radiotherapy with immune checkpoint inhibitors overcomes the immunosuppressive brain microenvironment in non‐small cell lung cancer (NSCLC) brain metastases. The synergy enhances immune cell infiltration and systemic anti‐tumor activity, improving survival outcomes for patients.
Silai Yu, Jianjiao Ni, Hongru Chen, Nuan Weng, Xi Yang, Xiao Chu, Li Chu, Zhengfei Zhu   +7 more
wiley   +1 more source

Discovery of edodine, a natural compound from Lentinula edodes with antibacterial activity for the biological control of fire blight pathogen Erwinia amylovora

Pest Management Science, EarlyView.
Novel edodine was identified from Lentinula edodes HK761, exhibiting biocontrol potential against fire blight by affecting motility, intracellular ATP level, and cell division of Erwinia amylovora. Abstract BACKGROUND In the search for biological resources with antibacterial activity against Erwinia amylovora, the culture filtrate of Lentinula edodes ...
Yeong Seok Kim, Jae Woo Han, Bomin Kim, Chunggeon Lee, Daeui Park, Jaehyuk Choi, Gyung Ja Choi, Hun Kim   +7 more
wiley   +1 more source

Type II DNA topoisomerases in zebrafish development

, 2008
DNA topoisomerases are vital enzymes for major cellular processes like replication, transcription, and chromosome segregation. They play an essential role in solving DNA topological problems by catalysing the passage of DNA strands through each other via
Azrak, Sami
core  

Local selection rules that can determine specific pathways of DNA unknotting by type II DNA topoisomerases

, 2007
We performed numerical simulations of DNA chains to understand how local geometry of juxtaposed segments in knotted DNA molecules can guide type II DNA topoisomerases to perform very efficient relaxation of DNA knots.
Yannis Burnier, Alessandro Flammini, A. Flammini, Andrzej Stasiak, C. Weber, Stasiak, A., Flammini, A., Weber, C., Cedric Weber, Burnier, Y., Y. Burnier, A. Stasiak, Weber, C.; id_orcid   +12 more
core   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, EarlyView.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

DNA topoisomerases in life and death: implications in kinetoplastid protozoa

, 2004
Current biomedical research has its focus on the search for newer intervention strategies to control public health impact of parasitic diseases. The dramatic advances of molecular and cellular biology in recent times have provided opportunities for ...
Chowdhury, Arnab R., Majumder, Hemanta K.   +1 more
core   +1 more source