Results 131 to 140 of about 1,265,065 (269)
Heart failure medication to prevent cancer therapy–related cardiac dysfunction: A narrative review
British Journal of Pharmacology, EarlyView.Advances in oncological therapies have improved cancer survival but also have increased the clinical incidence of cancer therapy–related cardiac dysfunction (CTRCD), a spectrum of conditions ranging from subclinical biomarker or strain abnormalities to progressive heart failure and cardiogenic shock.
Fabian Voß +3 more
wiley +1 more source
Kinetoplast DNA: A Promising Drug Target for Treatment of Leishmaniasis
Journal of Mazandaran University of Medical Sciences, 2020 Leishmaniasis is a vector-borne zoonotic disease caused by various species of the genus Leishmania, (trypanosomatidae family) that is transmitted by phlebotomine sandflies.
Elham Kialashaki +4 more
doaj
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
The FEBS Journal, EarlyView.Chromosomal DNA double‐strand breaks (DSBs) are repaired by homologous recombination and nonhomologous end joining (NHEJ). Recent work has additionally established theta‐mediated end‐joining (TMEJ) as a mechanism for DSB joining. Cells lacking NHEJ and TMEJ can repair DSBs in a homology‐dependent manner.
Shinta Saito +6 more
wiley +1 more source
TOP1MT rs2293925 is an enhancer‐active regulatory SNP that shapes mitochondrial R‐loop dynamics
The FEBS Journal, EarlyView.This study shows how a common genetic variant of mitochondrial topoisomerase 1 (TOP1MT rs2293925) can influence mitochondrial gene regulation, DNA topology, and formation of noncanonical nucleic acid structures such as R‐loops. By linking this enhancer‐active variant to mitochondrial nucleic acid stress in cellular contexts relevant to amyotrophic ...
Dóra Varga +15 more
wiley +1 more source
Ploidy‐dependent modulation of DNA replication kinetics in Xenopus
The FEBS Journal, EarlyView.Using an interspecies replication system with Xenopus frog species of different ploidy levels, we investigated how DNA replication adapts to polyploidization. While replication was slower in tetraploid than in diploid nuclei, dodecaploid nuclei unexpectedly replicated faster than tetraploid nuclei. Our findings show that increasing genome size does not
Hemalatha Narassimprakash +4 more
wiley +1 more source
The Dynamic Interplay Between DNA Topoisomerases and DNA Topology. [PDF]
Biophys Rev, 2016 Seol Y, Neuman KC.
europepmc +2 more sources
Role of Supercoiling and Topoisomerases in DNA Knotting
DNADNA knots are deleterious for living cells if not removed. Several theoretical and simulation approaches address the question of how topoisomerases select the intermolecular passages that preferentially lead to unknotting rather than to the knotting of ...
Jorge Cebrián +6 more
doaj +1 more source
Clonal Hematopoiesis and CAR T Cell Therapy: From Biological Crosstalk to Clinical Implications
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Clonal hematopoiesis (CH) is increasingly recognized as a significant biological phenomenon in aging and cancer, marked by the expansion of hematopoietic stem and progenitor cells harboring somatic mutations in genes associated with myeloid neoplasms.
Wei Du +4 more
wiley +1 more source
Journal of Fish Diseases, EarlyView.ABSTRACT Monitoring antimicrobial resistance (AMR) in fish pathogens is essential for supporting sustainable aquaculture. In this study, susceptibility testing and genome sequencing were used to characterize the AMR profile of seven Flavobacterium psychrophilum originating from Danish rainbow trout farms (2019–2022).
Valentina L. Donati, Lone Madsen
wiley +1 more source