Results 221 to 230 of about 1,893,090 (266)

Introduction of a Double‐Headed Nucleotide Into G‐Quadruplex DNA: Position‐Dependent Stabilization and Structural Insights

Chemistry – A European Journal, EarlyView.
A double‐headed bis‐guanine (G) nucleotide (GG) was evaluated as a noncanonical building block in G‐quadruplexes (G4s). Biophysical and computational analyses reveal that GG can directly participate in G‐tetrads and strongly stabilize G4s in a position‐ and topology‐dependent manner. These findings establish design rules for using GG to engineer highly
Krista Urup, Peter Reinholdt, Kasper Munch Beck, Michael Petersen, Jean‐Louis Mergny, Poul Nielsen   +5 more
wiley   +1 more source

DNA Structure-Dependent Enrichment of Oxidative Lesions. [PDF]

Chem Res Toxicol
Zewail-Foote M, Klattenhoff AW, Vasquez KM.   +2 more
europepmc   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source

A WGCNA‐Based Approach to Identify Hub Genes Associated With TNM Staging in Urothelial Bladder Carcinoma

Cancer Nexus, EarlyView.
ABSTRACT In this study, we identified gene modules and representative candidate biomarkers linked to clinical progression in patients with UBC. Weighted gene co‐expression network analysis (WGCNA) was used to identify gene modules associated with TNM staging in UBC patients.
Arshia Azmoudeh
wiley   +1 more source

Can intrinsic loop energetics predict G-Quadruplex topology? [PDF]

PLoS Comput Biol
Jurkowski M, Kogut M, Ławicki M, Czub J.   +3 more
europepmc   +1 more source

How loop lengths shape topological preferences of two-tetrad G-quadruplexes. [PDF]

Nucleic Acids Res
Woś A, Zielińska K, Pasternak K, Pawłowicz-Perczak A, Gdaniec Z, Gudanis-Sobocińska D, Andrałojć W.   +6 more
europepmc   +1 more source

Chemical and Structural Engineering of Guide RNAs for Precision Genome Editing: From Design Principles to Clinical Applications. [PDF]

Chem Biol Drug Des
Kawamata M, Niwa S, Suzuki A.
europepmc   +1 more source

A New Framework to Empower Ecosystem Assessment Through the Integration of eDNA Inventories, Graph Theory and Niche Modelling. [PDF]

Ecol Lett
Alric B, Domaizon I, Laplace-Treyture C, Viollaz L, Rimet F.   +4 more
europepmc   +1 more source

Topological rules and anomalies in intramolecular G-quadruplex folding: a comprehensive study. [PDF]

Nucleic Acids Res
Granzhan A, Mouawad L.
europepmc   +1 more source

Azobenzene-Cored Amphiphilic Dendrimers: Molecular Photoswitching Controls Dendriplex Topology and Gene Delivery. [PDF]

Small Sci
Puerto-Madorrán MJ, Rivero-Barbarroja G, Benito JM, Maisonneuve S, Vélaz I, Di Giorgio C, Tros de Ilarduya C, Mendicuti F, Ortiz Mellet C, Xie J, García Fernández JM.   +10 more
europepmc   +1 more source