Results 231 to 240 of about 1,893,090 (266)
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Trends in Biotechnology, 2002
In living cells, genomic DNA is organized into multiple topological domains that restrict the rotation of the double helix and cause DNA supercoiling. DNA topology is important for the intranuclear DNA packaging and plays a role in the regulation of gene expression.
exaly +2 more sources
In living cells, genomic DNA is organized into multiple topological domains that restrict the rotation of the double helix and cause DNA supercoiling. DNA topology is important for the intranuclear DNA packaging and plays a role in the regulation of gene expression.
exaly +2 more sources
Topologically‐Interlocked Minicircles as Probes of DNA Topology and DNA‐Protein Interactions
Chemistry – A European Journal, 2022AbstractDNA minicircles exist in biological contexts, such as kinetoplast DNA, and are promising components for creating functional nanodevices. They have been used to mimic the topological features of nucleosomal DNA and to probe DNA‐protein interactions such as HIV‐1 and PFV integrases, and DNA gyrase.
Arivazhagan Rajendran +5 more
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Energetics of twisted DNA topologies
Biophysical Journal, 2021Our goal is to review the main theoretical models used to calculate free energy changes associated with common, torsion-induced conformational changes in DNA and provide the resulting equations hoping to facilitate quantitative analysis of both in vitro and in vivo studies.
Wenxuan, Xu, David, Dunlap, Laura, Finzi
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Choice Reviews Online, 2005
Abstract DNA as the genetic material is a topic of intense interest in the 21st century, with the genomes of many organisms having been sequenced. The double helix structure discovered by Watson and Crick 50 years ago is now very familiar and its importance for DNA function is widely appreciated.
Andrew D Bates, Anthony Maxwell
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Abstract DNA as the genetic material is a topic of intense interest in the 21st century, with the genomes of many organisms having been sequenced. The double helix structure discovered by Watson and Crick 50 years ago is now very familiar and its importance for DNA function is widely appreciated.
Andrew D Bates, Anthony Maxwell
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Interlocked DNA topologies for nanotechnology
Current Opinion in Biotechnology, 2017Interlocked molecular architectures are well known in supramolecular chemistry and are widely used for various applications like sensors, molecular machines and logic gates. The use of DNA for constructing these interlocked structures has increased significantly within the current decade.
Valero, J., Lohman, F., Famulok, M.
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Small DNA circles as probes of DNA topology
Biochemical Society Transactions, 2013Small DNA circles can occur in Nature, for example as protein-constrained loops, and can be synthesized by a number of methods. Such small circles provide tractable systems for the study of the structure, thermodynamics and molecular dynamics of closed-circular DNA.
Andrew D, Bates +4 more
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Expression of transfected DNA depends on DNA topology
Cell, 1986Supercoiled DNAs, especially those containing enhancers, yield markedly higher levels of expression than linearized DNA when transfected into CV-1 cells or L cells. Different templates, linear or supercoiled, enhancer-containing or not, saturate for expression at 2 micrograms DNA per dish, suggesting that one role for enhancers and supercoiling is to ...
H, Weintraub, P F, Cheng, K, Conrad
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DNA Topology in Heterochromatin (a Hypothesis)
Journal of Theoretical Biology, 2000A hypothesis explaining the known heterochromatin features--a compact DNA packaging, transcriptional inactivity, propensity to aggregate (stickiness) and position effect variegation-is described. The hypothesis is based on the assumption that DNA molecules in heterochromatin are topologically open and contain single-strand breaks in the regions with ...
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2013
In this expository chapter we give an elementary introduction to DNA and to proteins that can knot and link circular DNA, with a special focus on recombination. We also describe the Ernst and Sumners tangle model of the action of proteins on circular DNA.
Isabel K. Darcy +2 more
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In this expository chapter we give an elementary introduction to DNA and to proteins that can knot and link circular DNA, with a special focus on recombination. We also describe the Ernst and Sumners tangle model of the action of proteins on circular DNA.
Isabel K. Darcy +2 more
openaire +1 more source
2018
DNA holds the instructions for an organism’s development, reproduction, and, ultimately, death. It encodes much of the information a cell needs to survive and reproduce. It is important for inheritance and coding for proteins, and contains the genetic instruction guide for life and its processes.
Garrett Jones, Candice Reneé Price
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DNA holds the instructions for an organism’s development, reproduction, and, ultimately, death. It encodes much of the information a cell needs to survive and reproduce. It is important for inheritance and coding for proteins, and contains the genetic instruction guide for life and its processes.
Garrett Jones, Candice Reneé Price
openaire +1 more source