Results 231 to 240 of about 2,766,615 (303)

ECCFP: A consecutive full pass‐based bioinformatic analysis for eccDNA identification from long‐read sequencing data

iMetaOmics, EarlyView.
A new bioinformatics pipeline called ECCFP has been developed to improve the detection of extrachromosomal circular DNA (eccDNA) from long‐read sequencing data. ECCFP uses all consecutive full passes from individual reads for candidate eccDNA identification and consolidates candidate eccDNAs to generate accurate unique eccDNA.
Wang Li, Biyuan Miao, Jun Zhang, Qingsong Zeng, Tangxuan Zhang, Zetong Wu, Yusheng Song, Mengting Li, Lilu Guo, Juan Luo, Jingxiang Xu, Tianliang Liu, Shifu Chen, Jia Gu, Shaogui Wan   +14 more
wiley   +1 more source

Topoisomerases as Targets for Novel Drug Discovery. [PDF]

Pharmaceuticals (Basel)
Perdih A.
europepmc   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Detection of Structural Changes in G-Quadruplex-Forming DNA Oligonucleotides via DNA Methylation Based on Luminol Chemiluminescence Catalyzed by Myoglobin. [PDF]

Biosensors (Basel)
Inaba S, Kawai H, Tomizawa M, Miura D, Tsukakoshi K, Ikebukuro K.   +5 more
europepmc   +1 more source

Decoding temporal miRNA signatures of semen under in vitro exposure for forensic time since deposition estimation using machine learning‐driven modeling

Interdisciplinary Medicine, EarlyView.
This study develops a novel miRNA‐based framework for estimating the time since deposition of semen stains, combining small RNA sequencing with machine learning. Time‐dependent miRNA modules were identified using Mfuzz clustering and WGCNA, followed by a multi‐stage feature selection pipeline that reduced 261 candidate miRNAs to a minimal 7‐miRNA panel.
Meiming Cai, Qiong Lan, Tong Xie, Qinglin Liu, Ming Zhao, Xiaolian Wu, Xin Shi, Ruonan Shen, Yiman Wu, Chen Mao, Bin Cong, Bofeng Zhu   +11 more
wiley   +1 more source

Single-molecule magnetic tweezers reveal distinct dynamics and enhanced mechanical stability of ssDNA 31 and 52 knots. [PDF]

Nucleic Acids Res
Zhang Z, Zhang Y, Xue Z, Shang F, Liu Y, Le S, Chen H.   +6 more
europepmc   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Deep Learning Integration in Optical Microscopy: Advancements and Applications

Microscopy Research and Technique, EarlyView.
It explores the integration of DL into optical microscopy, focusing on key applications including image classification, segmentation, and computational reconstruction. ABSTRACT Optical microscopy is a cornerstone imaging technique in biomedical research, enabling visualization of subcellular structures beyond the resolution limit of the human eye ...
Pottumarthy Venkata Lahari, Sagnika Dutta, H. Deeksha, Samreen A. Patel, Budheswar Dehury, Nirmal Mazumder   +5 more
wiley   +1 more source

A Hybrid G‑Quadruplex Structure Formed by a Sequence from the MAX Gene. [PDF]

JACS Au
Hu X, Ni X, Lan W, Cao C.
europepmc   +1 more source

Complete chloroplast genome of Triticum aestivum cultivar ‘Keumkang’ from Korea (Poaceae) and comparative chloroplast genomes of the members of the Triticum genus

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Bread wheat (Triticum aestivum L.) is a major global food crop, and understanding its maternal lineage and genetic diversity is essential for breeding, authentication, and evolutionary studies. Chloroplast genomes provide valuable markers for phylogenetic inference and cultivar discrimination; however, conventional plant DNA ...
Kang‐Rae Kim, Changhyun Choi, Jung Sun Kim, Myung‐Hee Kim, Hwa Jin Jung, DaHye Jeon, Jin‐Hyun Kim   +6 more
wiley   +1 more source