A robust assay to measure DNA topology-dependent protein binding affinity. [PDF]
Nucleic Acids Res, 2015 DNA structure and topology pervasively influence aspects of DNA metabolism including replication, transcription and segregation. However, the effects of DNA topology on DNA-protein interactions have not been systematically explored due to limitations of ...
Litwin TR, Solà M, Holt IJ, Neuman KC.
europepmc +2 more sources
DNA Topology and Global Architecture of Point Centromeres
Cell Reports, 2015 DNA is wrapped in a left-handed fashion around histone octasomes containing the centromeric histone H3 variant CENP-A. However, DNA topology studies have suggested that DNA is wrapped in a right-handed manner around the CENP-A nucleosome that occupies ...
Ofelia Díaz-Ingelmo +4 more
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Adenylylation of Gyrase and Topo IV by FicT Toxins Disrupts Bacterial DNA Topology
Cell Reports, 2015 Toxin-antitoxin (TA) modules are ubiquitous molecular switches controlling bacterial growth via the release of toxins that inhibit cell proliferation.
Alexander Harms +8 more
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Pamoic acid and carbenoxolone specifically inhibit CRISPR/Cas9 in bacteria, mammalian cells, and mice in a DNA topology-specific manner [PDF]
Genome BiologyBackground Regulation of the target DNA cleavage activity of CRISPR/Cas has naturally evolved in a few bacteria or bacteriophages but is lacking in higher species.
Yuxuan Zhang +5 more
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Editorial: Chromosome architecture and DNA topology in prokaryotes [PDF]
Frontiers in Microbiology, 2023 Tamara Basta +2 more
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The Impact of DNA Topology and Guide Length on Target Selection by a Cytosine-Specific Cas9. [PDF]
ACS Synth Biol, 2017 Tsui TKM, Hand TH, Duboy EC, Li H.
europepmc +2 more sources
TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection. [PDF]
Mol Cell, 2016 Benarroch-Popivker D +21 more
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DNA topology confers sequence specificity to nonspecific architectural proteins. [PDF]
Proc Natl Acad Sci U S A, 2014 Wei J +4 more
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Topogami: Topologically Linked DNA Origami [PDF]
ACS Nanoscience Au, 2021 DNA origami is a widely used DNA nanotechnology that allows construction of two-dimensional and three-dimensional nanometric shapes. The designability and rigidity of DNA origami make it an ideal material for construction of topologically linked molecules such as catenanes, which are attractive for their potential as motors and molecular machines ...
Yusuke Sakai +4 more
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