Results 151 to 160 of about 256,848 (381)

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Advanced Science, EarlyView.
This work presents a creative pipeline for developing MDM2‐targeting PROTACs (MDM2‐PROTACs) for application in bone regeneration. The developed PROTACs (CL144 and CL174) are validated for their degradation efficiency and osteogenic effects in human BMSCs.
Sol Jeong, Jae‐Kook Cha, Wasim Ahmed, Jaewan Kim, Minsup Kim, Kyung Tae Hong, Wonji Choi, Sunjoo Choi, Tae Hyeon Yoo, Hyun‑Ju An, Seung Chan An, Jaemin Lee, Jimin Choi, Sun‐Young Kim, Jun‐Seok Lee, Soonchul Lee, Junwon Choi, Jin Man Kim   +17 more
wiley   +1 more source

Modelling the proliferation of transposable elements in populations under environmental stress [PDF]

arXiv, 2016
In this article, we investigate the evolution of sexual diploid populations which are hosts for active TE families. Our purpose is to explore the relationship between the environmental change, that influences such population and activity of those TEs that are present in genomes.
arxiv  

Enrichment analysis of Alu elements with different spatial chromatin proximity in the human genome [PDF]

, 2016
Transposable elements (TEs) have no longer been totally considered as “junk DNA” for quite a time since the continual discoveries of their multifunctional roles in eukaryote genomes.
A Antonaki, A Huda, A Nekrutenko, A Smallwood, AF Smit, AM Deaton, C Esnault, C Feschotte, CB Lowe, CT Ong, D Grover, D Grover, D Schmidt, D Xie, E Berezikov, E Lieberman-Aiden, E Wit de, E Yaffe, EP Nora, ES Lander, ES Lander, F Cui, G Bourque, G Kunarso, G Li, G Li, GA Maston, GJ Faulkner, GN Gallus, H Santos-Rosa, H Santos-Rosa, H Xie, HH Kazazian Jr, IK Jordan, J Banerji, J Dekker, J Dostie, J Jurka, J Jurka, J Ule, JA Yoder, JE Hambor, JF Brookfield, JF Brookfield, JM Chen, JR Dixon, JR Korenberg, K Ahn, K Kaer, KC Wang, L Lin, L Teng, M Hackenberg, M Simonis, M Weber, MA Batzer, MG Kidwell, MH Kagey, MJ Fullwood, MM Suzuki, ND Heintzman, NR Smalheiser, P Jin, P Medstrand, P Polak, R Cordaux, R Eskeland, R Lister, R Schneider, R Sorek, RD Hawkins, S Shen, S Winkler, SD Gillies, SL Oei, T Pastor, T Wicker, V Kapitonov, VJ Lynch, WD Gifford, Y Lu, Y Quentin, Y Quentin, Y Zhang   +83 more
core   +3 more sources

Mammalian transposable elements and their impacts on genome evolution

Chromosome Research, 2018
Transposable elements (TEs) are genetic elements with the ability to mobilize and replicate themselves in a genome. Mammalian genomes are dominated by TEs, which can reach copy numbers in the hundreds of thousands.
Roy N Platt, Michael W. Vandewege, D. Ray   +2 more
semanticscholar   +1 more source

SSRP1/SLC3A2 Axis in Arginine Transport: A New Target for Overcoming Immune Evasion and Tumor Progression in Peripheral T‐Cell Lymphoma

Advanced Science, EarlyView.
Enhanced arginine uptake is a critical feature of metabolic reprogramming in PTCL, characterized by elevated expression of the arginine transporter SLC3A2. SLC3A2‐mediated arginine uptake facilitates PTCL proliferation and survival by enhancing OXPHOS metabolism and inducing immune evasion.
Yimin Ren, Lei Fan, Ling Wang, Yanping Liu, Jie Zhang, Boya Wang, Ruize Chen, Xiao Chen, Lingyu Zhuang, Yaping Zhang, Handong Sun, Jianyong Li, Wenyu Shi, Hui Jin   +13 more
wiley   +1 more source

Divergence and introgression among the virilis group of Drosophila

Evolution Letters, Volume 6, Issue 6, Page 537-551, December 2022., 2022
Abstract Speciation with gene flow is now widely regarded as common. However, the frequency of introgression between recently diverged species and the evolutionary consequences of gene flow are still poorly understood. The virilis group of Drosophila contains 12 species that are geographically widespread and show varying levels of prezygotic and ...
Leeban H. Yusuf, Venera Tyukmaeva, Anneli Hoikkala, Michael G. Ritchie   +3 more
wiley   +1 more source

Activity and Silencing of Transposable Elements in C. elegans

DNA
Since the discovery of transposable elements (TEs) in maize in the 1940s by Barbara McClintock transposable elements have been described as junk, as selfish elements with no benefit to the host, and more recently as major determinants of genome structure
Sylvia E. J. Fischer
doaj   +1 more source

Meeting report: mobile genetic elements and genome plasticity 2018

Mobile DNA, 2018
The Mobile Genetic Elements and Genome Plasticity conference was hosted by Keystone Symposia in Santa Fe, NM USA, February 11–15, 2018. The organizers were Marlene Belfort, Evan Eichler, Henry Levin and Lynne Maquat.
John M. Abrams, Irina R. Arkhipova, Marlene Belfort, Jef D. Boeke, M. Joan Curcio, Geoffrey J. Faulkner, John L. Goodier, Ruth Lehmann, Henry L. Levin   +8 more
doaj   +1 more source

The epigenomic landscape of transposable elements across normal human development and anatomy

Nature Communications, 2019
Transposable elements (TEs) have deposited functional regulatory elements throughout the human genome. Although most are silenced, certain TEs have been co-opted by the host.
Erica C. Pehrsson, Mayank N. K. Choudhary, Vasavi Sundaram, Ting Wang   +3 more
semanticscholar   +1 more source

PLXDC1+ Tumor‐Associated Pancreatic Stellate Cells Promote Desmoplastic and Immunosuppressive Niche in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
This study uncovers the activation, heterogeneity, and regulatory roles of pancreatic stellate cells (PSCs) at single‐cell and spatial levels. It further identifies PLXDC1+ PSCs near aggressive LRRC15+ cancer‐associated myofibroblasts and SPP1+ macrophages, forming a desmoplastic and immunosuppressive tumor niche that promotes CD8+ T cell exhaustion ...
Yanhua Du, Yizhou Zhao, Judong Li, Jiaxin Wang, Shenglan You, Yao Zhang, Li Zhang, Jihong Yang, Hamid Alinejad‐Rokny, Shujie Cheng, Chenghao Shao, Duowu Zou, Youqiong Ye   +12 more
wiley   +1 more source