Results 201 to 210 of about 149,433 (366)
Approaches to repurposing reverse transcriptase antivirals in cancer
British Journal of Clinical Pharmacology, EarlyView.This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head +2 more
wiley +1 more source
Exploring Repetitive DNA Landscapes Using REPCLASS, a Tool That Automates the Classification of Transposable Elements in Eukaryotic Genomes [PDF]
, 2009 Cédric Feschotte +4 more
openalex +1 more source
Biotechnology Progress, EarlyView.Abstract Epigenetic regulation plays an important role in cell fate reprogramming. Here, we found that inhibitors of epigenetic modifiers, including VPA, TSA, and 5‐Aza‐2'‐deoxycytidine, can induce phenotypic transformation from Jurkat cells into B‐cell‐like cells. When Jurkat cells were treated with 5‐Aza combined with VPA, B cell and stem cell marker
Wenjin Xi +11 more
wiley +1 more source
Cancer Communications, EarlyView.Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolism affects the tumor microenvironment (TME) in pancreatic ...
Mengyi Lao +12 more
wiley +1 more source
OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide [PDF]
Hugo Sepúlveda +20 more
openalex +2 more sources
Methods for Controlling Small GTPase Activity
ChemBioChem, EarlyView.This concept highlights recent and emerging methods for controlling small GTPase activity, encompassing both small‐molecule‐based approaches and protein engineering strategies. The use of these approaches to advance the understanding of small GTPase function, current limitations, and future outlook is discussed.
Benjamin Faulkner +3 more
wiley +1 more source
Low coverage sequencing for repetitive DNA analysis in Passiflora edulis Sims: citogenomic characterization of transposable elements and satellite DNA [PDF]
, 2019 Vanessa Carvalho Cayres Pamponét +7 more
openalex +1 more source
ChemistryEurope, EarlyView.It is shown that pnictogenium ions [R2E]+ (E = P, As, Sb, Bi) either insert into the E′E″ bond or coordinate to the phosphorus lone‐pair of the tetrahedral heterodipnictogen complexes [{CpMo(CO)2}2(μ,η2:2‐E′E″)] (E ≠ E″ = P, As, Sb). Reactivity studies of the obtained three‐membered interpnictogen chains with another tetrahedrane unit allowed for the ...
Lisa Zimmermann +6 more
wiley +1 more source