Results 211 to 220 of about 256,848 (381)

Global DNA hypomethylation of Alu and LINE-1 transposable elements as an epigenetic biomarker of anti-tuberculosis drug-induced liver injury [PDF]

, 2021
Wanvisa Udomsinprasert, Wanchaloem Sakuntasri, Jiraphun Jittikoon, Usa Chaikledkaew, Sittisak Honsawek, Wasun Chantratita, Sukanya Wattanapokayakit, Surakameth Mahasirimongkol   +7 more
openalex   +1 more source

Endogenous Retroelement Activation is Implicated in Interferon‐α Production and Anti–Cyclic Citrullinated Peptide Autoantibody Generation in Early Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Endogenous retroelements (EREs) stimulate type 1 interferon (IFN‐I) production but have not been explored as potential interferonogenic triggers in rheumatoid arthritis (RA). We investigated ERE expression in early RA (eRA), a period in which IFN‐I levels are increased.
Faye A. H. Cooles, Gemma Vidal Pedrola, Najib Naamane, Arthur G. Pratt, Ben Barron‐Millar, Amy E. Anderson, Catharien M. U. Hilkens, John Casement, Vincent Bondet, Darragh Duffy, Fan Zhang, Ruchi Shukla, John D. Isaacs   +12 more
wiley   +1 more source

A unified framework to analyze transposable element insertion polymorphisms using graph genomes

Nature Communications
Transposable elements are ubiquitous mobile DNA sequences generating insertion polymorphisms, contributing to genomic diversity. We present GraffiTE, a flexible pipeline to analyze polymorphic mobile elements insertions.
Cristian Groza, Xun Chen, Travis J. Wheeler, Guillaume Bourque, Clément Goubert   +4 more
doaj   +1 more source

Atherosclerotic Plaque Progression and Incident Cardiovascular Events in a 10‐Year Prospective Study of Patients With Systemic Lupus Erythematosus: The Impact of Persistent Cardiovascular Risk Factor Target Attainment and Sustained DORIS Remission

Arthritis &Rheumatology, EarlyView.
Objective Cardiovascular disease (CVD) is a leading cause of death in individuals with systemic lupus erythematosus (SLE). We assessed atherosclerotic plaque progression and incident cardiovascular events in patients with SLE over a 10‐year follow‐up.
Nikolaos Papazoglou, Petros P. Sfikakis, Maria G. Tektonidou   +2 more
wiley   +1 more source

Coral Restoration in the Omics Era: Development of Point‐of‐Care Tools for Monitoring Disease, Reproduction, and Thermal Stress

BioEssays, EarlyView.
Shown are different multi‐omics approaches that are used to identify potential biomarkers of coral health and disease. The integration of these data streams, using cutting‐edge molecular diagnostic technologies, including colorimetric dipsticks, lateral flow assays, and colorimetric LAMP (loop‐mediated isothermal amplification), holds the promise to ...
Erin E. Chille, Timothy G. Stephens, Shrinivas Nandi, Haoyu Jiang, Michael J. Gerdes, Olivia M. Williamson, Alexander Neufeld, Phanor Montoya‐Maya, Debashish Bhattacharya   +8 more
wiley   +1 more source

Characterization of large transgene integrations in Chinese hamster ovary cells using a bioengineered mammalian transposase

Biotechnology Progress, EarlyView.
Abstract We present the first use of a bioengineered mammalian transposase system derived from Myotis lucifugus (bMLT) for integration of expression vectors into the CHO genome, focusing on GFP and trastuzumab production. Initially, CHO‐K1 cells are transfected with a GFP reporter and varying amounts of bMLT DNA or mRNA.
Nicolas Marx, Anna‐Maria Otte, Klaus Leitner, Rehmadanta Sitepu, Thomas Berger, Veronika Schäpertöns, Christian G. Huber, Quan Zhu, Sandeep Nema, Joseph J. Higgins, Nicole Borth   +10 more
wiley   +1 more source

Process intensification of the baculovirus expression vector system using a perfusion process with a low multiplicity of infection at high cell concentrations

Biotechnology Progress, EarlyView.
Abstract The emergence of new viruses and the spread of existing pathogens necessitate efficient vaccine production methods. The baculovirus expression vector system (BEVS) is an efficient and scalable system for subunit and virus‐like particle vaccine production and gene therapy vectors.
Jort J. Altenburg, Brenda E. Juarez‐Garza, Jelle van Keimpema, Linda van Oosten, Gorben P. Pijlman, Monique M. van Oers, René H. Wijffels, Dirk E. Martens   +7 more
wiley   +1 more source

Long Term Weight Cycling Affects Fecal Microbiota of Mice

Molecular Nutrition &Food Research, Volume 66, Issue 23, December 2022., 2022
Fighting obesity through dieting is not always sustained and results in a subsequent weight gain, a phenomenon referred to as weight cycling. We determined whether weight cycling affects mouse fecal bacteria on a long‐term basis. Compared to continuous High Fat (HF) or Low Fat (LF) diets, cyclic diet specifically alters the composition and function of ...
Christèle Humblot, Yohannes Seyoum, Williams Turpin, Rachida Mrabt, Edward O. List, Darlene E. Berryman, Elizabeth A. Jensen, Elahu G. Sustarsic, John J. Kopchick, Jean‐Marc Ricort   +9 more
wiley   +1 more source

DNA Methylation and Histone H1 Jointly Repress Transposable Elements and Aberrant Intragenic Transcripts.

Molecules and Cells, 2019
Jaemyung Choi, David B. Lyons, M. Y. Kim, Jonathan D. Moore, Daniel Zilberman   +4 more
semanticscholar   +1 more source

Supplementary Material for: Characterization and Genomic Organization of PERI, a Repetitive DNA in the Drosophila buzzatii Cluster Related to DINE-1 Transposable Elements and Highly Abundant in the Sex Chromosomes

, 2010
Kuhn G.C.S., J. S. Heslop‐Harrison
openalex   +2 more sources