Results 221 to 230 of about 256,848 (381)

A synthetic platform for developing recombinant adeno‐associated virus type 8 producer cell lines

Biotechnology Progress, EarlyView.
Abstract Recombinant adeno‐associated virus (rAAV) is one of the most widely used viral vectors for gene therapy. It is used in very high doses for the treatment of many diseases, making large‐scale production for clinical applications challenging. We have established a synthetic biology‐based platform to construct stable production cell lines, which ...
Yu‐Chieh Lin, Han‐Jung Kuo, Min Lu, Thomas Mahl, George Aslanidi, Wei‐Shou Hu   +5 more
wiley   +1 more source

Population Genetics and Molecular Evolution of DNA Sequences in Transposable Elements. I. A Simulation Framework

, 2013
Taizo Kijima, Hideki Innan
openalex   +1 more source

The structure of the regulatory region of the rat L1 (L1Rn, long interspersed repeated) DNA family of transposable elements [PDF]

, 1988
Anthony V. Furano, Susan M. Robb, Frank T. Robb   +2 more
openalex   +1 more source

5‐Aza combined with VPA reprograms human T lineage acute leukemia Jurkat cells into B‐cell‐like cells by epigenetic activation of PAX5

Biotechnology Progress, EarlyView.
Abstract Epigenetic regulation plays an important role in cell fate reprogramming. Here, we found that inhibitors of epigenetic modifiers, including VPA, TSA, and 5‐Aza‐2'‐deoxycytidine, can induce phenotypic transformation from Jurkat cells into B‐cell‐like cells. When Jurkat cells were treated with 5‐Aza combined with VPA, B cell and stem cell marker
Wenjin Xi, Guoxu Zheng, Xu Chen, Baile Zuo, Wei Wang, Yufang Li, Chunmei Zhang, Jie Chu, Xiuli Mu, Weihong Wen, Tao Wang, An‐Gang Yang   +11 more
wiley   +1 more source

Advances in analytical microfluidic workflows for differential cancer diagnosis

Nano Select, Volume 4, Issue 1, Page 1-47, January 2023., 2023
Microfluidics holds a great potential for an analytical examination of liquid biopsy and the development of point‐of‐care testing devices. This review overviews fundamentals and technological breakthroughs of immunolabeled and label‐free analytical microfluidic devices for screening and examining CTCs, describes engineering‐driven workflows for ...
Morteza Hasanzadeh Kafshgari, Oliver Hayden   +1 more
wiley   +1 more source

Loss of Transposase-DNA Interaction May Underlie the Divergence of mariner Family Transposable Elements and the Ability of More than One mariner to Occupy the Same Genome [PDF]

, 2001
David J. Lampe, Kimberly K. O. Walden, Hugh M. Robertson   +2 more
openalex   +1 more source

Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages

Cancer Communications, EarlyView.
Abstract Background Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti‐PD‐1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response to anti‐PD‐1 therapy is necessary to design more effective immunotherapies for GBM.
Rongrong Zhao, Ziwen Pan, Jiawei Qiu, Boyan Li, Yanhua Qi, Zijie Gao, Wei Qiu, Weijie Tang, Xiaofan Guo, Lin Deng, Gang Li, Hao Xue   +11 more
wiley   +1 more source

Correction: DNA Topoisomerase 1α Promotes Transcriptional Silencing of Transposable Elements through DNA Methylation and Histone Lysine 9 Dimethylation in Arabidopsis

, 2015
Thanh Theresa Dinh, Lei Gao, Xigang Liu, Dongming Li, Shengben Li, Yuanyuan Zhao, Michael L O'Leary, Brandon Le, Robert J. Schmitz, Pablo A. Manavella, Shaofang Li, Detlef Weigel, Olga Pontes, J Ecker, Xuemei Chen   +14 more
openalex   +2 more sources

Exploring Repetitive DNA Landscapes Using REPCLASS, a Tool That Automates the Classification of Transposable Elements in Eukaryotic Genomes [PDF]

, 2009
Cédric Feschotte, Umeshkumar Keswani, Nirmal Ranganathan, Marcel L. Guibotsy, David Levine   +4 more
openalex   +1 more source

Profiling Serine Hydrolases in the Leishmania Host‐Pathogen Interactome Using Cell‐Permeable Activity‐Based Fluorophosphonate Probes

ChemBioChem, Accepted Article.
Leishmaniasis, a vector borne neglected tropical disease, caused by the protozoan parasite Leishmania, is a major global public health challenge with millions of new cases annually. Treatment of leishmaniasis is difficult for many reasons including a multiple life‐cycle stages, involving both an infective insect vector form, the promastigote, and a ...
Jaime A. Isern, Exequiel O.J. Porta, Karunakaran Kalesh, Zisis Koutsogiannis, Davide Cazzola, Ehmke Pohl, Paul Denny, Patrick G. Steel   +7 more
wiley   +1 more source