Results 181 to 190 of about 2,856,528 (208)
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In vivo targeting of DNA vaccines to dendritic cells using functionalized gold nanoparticles.
Biomaterials Science, 2019The clinical success of dendritic cell (DC)-based genetic immunization remains critically dependent on the availability of effective and safe nano-carriers for targeting antigen-encoded DNA vaccines to DCs, the most potent antigen-presenting cells in the
S. K. Gulla +7 more
semanticscholar +1 more source
Frontiers in Bioscience, 2003
Human papillomaviruses (HPV), particularly HPV type 16, are the primary etiologic agent of cervical cancer. Thus, HPV-associated cervical malignancies might be prevented or treated by induction of the appropriate virus-specific immune responses in patients.
Michelle, Moniz +3 more
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Human papillomaviruses (HPV), particularly HPV type 16, are the primary etiologic agent of cervical cancer. Thus, HPV-associated cervical malignancies might be prevented or treated by induction of the appropriate virus-specific immune responses in patients.
Michelle, Moniz +3 more
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2014
Multiple sclerosis (MS) is the most common inflammatory, demyelinating, and neurodegenerative disorder of the central nervous system (CNS) in humans. Although the etiology of MS remains unknown, several lines of evidence support the notion that autoimmunity against components of the myelin sheath plays a major role in susceptibility to and development ...
Nicolás, Fissolo +2 more
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Multiple sclerosis (MS) is the most common inflammatory, demyelinating, and neurodegenerative disorder of the central nervous system (CNS) in humans. Although the etiology of MS remains unknown, several lines of evidence support the notion that autoimmunity against components of the myelin sheath plays a major role in susceptibility to and development ...
Nicolás, Fissolo +2 more
openaire +2 more sources
Microbes and Infection, 2005
Plasmid DNA vaccination against tuberculosis is a very powerful and easy method for the induction of strong humoral responses, CD4+ mediated secretion of Th1 cytokines and CD8+ mediated CTL activity in mice. Tuberculosis DNA vaccines have not been assessed so far in humans, and clinical trials with DNA in general have been somewhat disappointing ...
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Plasmid DNA vaccination against tuberculosis is a very powerful and easy method for the induction of strong humoral responses, CD4+ mediated secretion of Th1 cytokines and CD8+ mediated CTL activity in mice. Tuberculosis DNA vaccines have not been assessed so far in humans, and clinical trials with DNA in general have been somewhat disappointing ...
openaire +2 more sources
Scandinavian Journal of Infectious Diseases, 2001
DNA vaccines have been the subject of intense investigation for the past 10 y, during which time several tuberculosis (TB) DNA vaccines have been shown to confer protective immunity in animal models. So far, proof of principle for priming of immune responses by a naked DNA vaccine (malaria) has been demonstrated in humans, but potency remains a ...
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DNA vaccines have been the subject of intense investigation for the past 10 y, during which time several tuberculosis (TB) DNA vaccines have been shown to confer protective immunity in animal models. So far, proof of principle for priming of immune responses by a naked DNA vaccine (malaria) has been demonstrated in humans, but potency remains a ...
openaire +2 more sources
2003
Vaccination has relied, in general, on two technologies for the production of antigenic material suitable for the generation of a protective immune response; live infectious agents and inactivated or subunit vaccine preparations. Live infectious agents generally are most efficacious, but there is always a risk factor when using this type of vaccine ...
S, van Drunen Littel-van den Hurk +2 more
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Vaccination has relied, in general, on two technologies for the production of antigenic material suitable for the generation of a protective immune response; live infectious agents and inactivated or subunit vaccine preparations. Live infectious agents generally are most efficacious, but there is always a risk factor when using this type of vaccine ...
S, van Drunen Littel-van den Hurk +2 more
openaire +2 more sources
DNA Vaccines and Intradermal Vaccination by DNA Tattooing
2010Over the past two decades, DNA vaccination has been developed as a method for the induction of immune responses. However, in spite of high expectations based on their efficacy in preclinical models, immunogenicity of first generation DNA vaccines in clinical trials was shown to be poor, and no DNA vaccines have yet been licensed for human use.
K, Oosterhuis +3 more
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Current Drug Targets - Immune, Endocrine & Metabolic Disorders, 2001
Genes that code for the production of protein antigens have been cloned and recombined with plasmids. Gene-plasmid constructs have been amplified in a bacterial host, purified and administered to a mammalian host. The gene is expressed in the host and the antigen that is produced induces an immune response.
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Genes that code for the production of protein antigens have been cloned and recombined with plasmids. Gene-plasmid constructs have been amplified in a bacterial host, purified and administered to a mammalian host. The gene is expressed in the host and the antigen that is produced induces an immune response.
openaire +2 more sources
International Journal of Pharmaceutical Medicine, 2005
Compared with conventional approaches, DNA vaccine technology is a relatively new methodology for producing effective vaccines and has the major advantage of being simple and not requiring any special techniques for the purification and characterisation of recombinant proteins in the correct structure and conformation.
Indresh K. Srivastava, Manmohan Singh
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Compared with conventional approaches, DNA vaccine technology is a relatively new methodology for producing effective vaccines and has the major advantage of being simple and not requiring any special techniques for the purification and characterisation of recombinant proteins in the correct structure and conformation.
Indresh K. Srivastava, Manmohan Singh
openaire +1 more source
Vaccine, 2002
DNA vaccines have been the subjects of much effort over the past decade due to their ability to induce broad-based immune responses and protection in various animal models of infectious and non-infectious diseases. In particular, influenza DNA vaccines have been well studied.
openaire +2 more sources
DNA vaccines have been the subjects of much effort over the past decade due to their ability to induce broad-based immune responses and protection in various animal models of infectious and non-infectious diseases. In particular, influenza DNA vaccines have been well studied.
openaire +2 more sources