Results 61 to 70 of about 2,856,528 (208)

Immune efficacy of DNA vaccines based on oprL and oprF genes of Pseudomonas aeruginosa in chickens

Poultry Science, 2018
Pseudomonas aeruginosa (P. aeruginosa) is a zoonotic pathogen that can infect a variety of animals, including poultry. However, as there is no commercial vaccine available it is imperative that new and effective vaccines are developed.
Q. Gong, M. Ruan, M. Niu, C. Qin, Y. Hou, J. Guo   +5 more
semanticscholar   +1 more source

Emerging immunopharmacological targets in multiple sclerosis. [PDF]

, 2015
Inflammatory demyelination of the central nervous system (CNS) is the hallmark of multiple sclerosis (MS), a chronic debilitating disease that affects more than 2.5 million individuals worldwide. It has been widely accepted, although not proven, that the
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core   +2 more sources

Antirabies DNA Immunization

Проблемы особо опасных инфекций, 2010
Cited are literary data related to the development of DNA vaccines against rabies virus. Research results regarding gene vaccination of different models of laboratory animals and different ways of vaccine introduction are presented.
I. V. Tuchkov, A. K. Nikiforov
doaj   +1 more source

DNA Vaccines: Regulatory Considerations and Safety Aspects.

Current Issues in Molecular Biology, 2017
DNA vaccines have great potential as preventive or therapeutic vaccines against viral, bacterial, or parasitic diseases as well as cancer, and may also be used as gene therapy products.
A. Myhr
semanticscholar   +1 more source

Nanoplasmid Vectors Co-expressing Innate Immune Agonists Enhance DNA Vaccines for Venezuelan Equine Encephalitis Virus and Ebola Virus

Molecular Therapy: Methods & Clinical Development, 2020
DNA vaccines expressing codon-optimized Venezuelan equine encephalitis virus (VEEV) and Ebola virus (EBOV) glycoprotein genes provide protective immunity to mice and nonhuman primates when delivered by intramuscular (IM) electroporation (EP).
John J. Suschak, Lesley C. Dupuy, Charles J. Shoemaker, Carolyn Six, Steven A. Kwilas, Kristin W. Spik, James A. Williams, Connie S. Schmaljohn   +7 more
doaj   +1 more source

Immune responses and protective efficacy of a trivalent combination DNA vaccine based on oprL, oprF and flgE genes of Pseudomonas aeruginosa

Veterinární Medicína, 2023
Pseudomonas aeruginosa is an infectious pathogenic bacteria infecting many different species of animals. Currently, it lacks a commercial vaccine. In this study, three monovalent DNA vaccines (poprL, poprF, and pflgE), three bivalent combination DNA ...
Q Gong, Y Li, W Zhai, M Niu
doaj   +1 more source

A Novel Formulation Strategy to Deliver Combined DNA and VLP Based HPV Vaccine

Journal of Pharmacy & Pharmaceutical Sciences, 2019
Human papillomaviruses (HPV) are small, double-stranded DNA viruses that cause cervical cancer, the second most lethal cancer among women in the world. Currently, two vaccines are on the market for preventing HPV-caused cervical cancers and warts.
Mohammad Nasir Uddin, Brittany Henry, Kewan D Carter, Monzurul a Roni, Samir S Kouzi   +4 more
doaj   +1 more source

Mucosal vaccines — fortifying the frontiers

Nature reviews. Immunology, 2021
Mucosal vaccines offer the potential to trigger robust protective immune responses at the predominant sites of pathogen infection. In principle, the induction of adaptive immunity at mucosal sites, involving secretory antibody responses and tissue ...
E. Lavelle, Ross W. Ward
semanticscholar   +1 more source

A Comparison of Plasmid DNA and mRNA as Vaccine Technologies

Vaccines, 2019
This review provides a comparison of the theoretical issues and experimental findings for plasmid DNA and mRNA vaccine technologies. While both have been under development since the 1990s, in recent years, significant excitement has turned to mRNA ...
Margaret A. Liu
doaj   +1 more source

Needle-Free Devices and CpG-Adjuvanted DNA Improve Anti-HIV Antibody Responses of Both DNA and Modified Vaccinia Ankara-Vectored Candidate Vaccines

Vaccines, 2023
The combination of mosaic Gag and CAP256 envelope in an HIV vaccine regimen comprising DNA prime and modified vaccinia Ankara (MVA) boost followed by protein boost has previously been shown to generate robust autologous Tier 2 neutralizing antibodies ...
Rosamund Chapman, Michiel van Diepen, Nicola Douglass, Tandile Hermanus, Penny L. Moore, Anna-Lise Williamson   +5 more
doaj   +1 more source