Results 211 to 220 of about 740,027 (264)

Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys

Advanced Science, EarlyView.
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si   +10 more
wiley   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

Advanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu, Yuanyuan Yu, Guanyou Huang, Jinnan Li, Chao Yang, Aizhuan Long, Jia Tang, Tengxiang Chen, Shuyun Zhao, Tuo Zhang   +9 more
wiley   +1 more source

Programmable Klebsiella pneumoniae Phage Tropism Enabled by Scalable Receptor‐Binding Protein Mining and Modular Assembly

Advanced Science, EarlyView.
This work introduces a scalable, data‐driven strategy that turns the vast sequence diversity of phage receptor‐binding proteins into modular tools for engineering customizable phages. By clustering and experimentally validating diverse RBPs, the authors build an accurate map linking sequence to host specificity and create plug‐and‐play modules that ...
Shisong Jing, Yiyao Song, Xianbiao Bi, Yuqin Song, Dawei Wei, Jiangqing Huang, Yuan Zeng, Gang Zhang, Rong Zhang, Chao Wang, Jie Feng   +10 more
wiley   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

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Herpes simplex virus DNA

Virology, 1968
Abstract Herpes simplex virus DNA was isolated in an intact form by treating the virus particles with detergents. An average molecular weight of 100 × 106 daltons was determined for herpes simplex virus DNA, both by electron microscopy and by zone centrifugation in sucrose gradients.
Y, Becker, H, Dym, I, Sarov
openaire   +2 more sources

Studies on vaccinia virus DNA

Virology, 1967
Abstract A method has been developed for the isolation of intact DNA genomes from purified vaccinia virions. A molecular weight of 150 × 106 to 170 × 106 daltons was determined for vaccinia virus DNA molecules by zone centrifugation and electron microscopy, respectively.
I, Sarov, Y, Becker
openaire   +2 more sources

DNA virus maturation

Journal of Cellular Physiology, 1969
Maturation of bacterial viruses requires the formation of mature viral nucleic acid in the form found in progeny virus particles, the “packaging” of this viral nucleic acid within a capsule, and the assembly of “packaged” nucleic acid with the accessory structures necessary for infectivity.
openaire   +3 more sources

HERPES SIMPLEX VIRUS DNA REPLICATION

Annual Review of Biochemistry, 1997
The Herpesviridae comprise a large class of animal viruses of considerable public health importance. Of the Herpesviridae, replication of herpes simplex virus type-1 (HSV-1) has been the most extensively studied. The linear 152-kbp HSV-1 genome contains three origins of DNA replication and approximately 75 open-reading frames.
P E, Boehmer, I R, Lehman
openaire   +2 more sources

DNA virus replication

Journal of Clinical Virology, 2000
Abstract DNA viruses have always been the most important model systems for eukaryotic DNA replication. Add to this the clinical significance of these human pathogens- 99% of the population of the world is infected with at least one of the viruses discussed in this volume (hepatitis B virus, Eptstein Barr virus or herpes simplex virus)
openaire   +2 more sources

Infectivity of visna virus DNA

Virology, 1976
Abstract Deoxyribonucleic acid isolated from cells infected with the RNA containing slow virus visna confers on uninfected cells the capacity to synthesize new virus. The cytopathic agent isolated in these experiments has the biological and biochemical properties of visna virus, and the active material is DNA by several criteria, the most important ...
A T, Haase, B L, Traynor, P E, Ventura, D W, Alling   +3 more
openaire   +2 more sources