Results 111 to 120 of about 614,581 (300)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Potential Application of the CRISPR/Cas9 System against Herpesvirus Infections. [PDF]

, 2018
The CRISPR/Cas9 system has been applied in the genome editing and disruption of latent infections for herpesviruses such as the herpes simplex virus, Epstein⁻Barr virus, cytomegalovirus, and Kaposi's sarcoma-associated herpesvirus.
Chen, Yuan-Chuan, Liu, Fenyong, Sheng, Jingxue, Trang, Phong   +3 more
core   +2 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

A Liquid Crystal Model of Viral DNA Encapsidation

, 2017
A liquid crystal continuum modeling framework for icosahedra bacteriophage viruses is developed and tested. The main assumptions of the model are the chromonic columnar hexagonal structure of confined DNA, the high resistance to bending and the phase ...
Arsuaga, Javier, Calderer, Maria-Carme, Hiltner, Lindsey, Vazquez, Mariel   +3 more
core  

The Origin and Evolution of Viruses as Molecular Organisms [PDF]

, 2009
Viruses are the most abundant life forms and the repertoire of viral genes is greater than that of cellular genes. It is also evident that viruses have played a major role in driving cellular evolution, and yet, viruses are not part of mainstream biology,
Claudiu I. Bandea
core   +2 more sources

Bacteriophages and their structural organisation [PDF]

, 2012
Viruses are extremely small infectious particles that are not visible in a light microscope, and are able to pass through fine porcelain filters. They exist in a huge variety of forms and infect practically all living systems: animals, plants ...
Orlova, Elena
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Structural basis for CRISPR RNA-guided DNA recognition by Cascade [PDF]

, 2011
The CRISPR (clustered regularly interspaced short palindromic repeats) immune system in prokaryotes uses small guide RNAs to neutralize invading viruses and plasmids.
A Bolotin, A Noy, AJR Heck, AL Gnatt, Albert J R Heck, AM Maxam, Ambrosius P L Snijders, Arjan Barendregt, B Wiedenheft, Blake Wiedenheft, C Hale, C Pourcel, CR Hale, D Han, DH Haft, DY Lee, Edze R Westra, Egbert J Boekema, Esther van Duijn, FJ Mojica, FJ Mojica, FV Karginov, GT Oostergetel, H Deveau, H Deveau, J Carte, J Li, J van der Oost, JB Ma, JE Garneau, Jelle B Bultema, Jennifer A Doudna, John van der Oost, K Lorenzen, K Yu, Kaihong Zhou, KS Makarova, LA Marraffini, LA Marraffini, LA Marraffini, M Thomas, M van Heel, M Zhou, Magnus Lundgren, Marieke R Beijer, Mark J Dickman, Matthijs M Jore, MJ Dickman, MR Singleton, N Tahallah, P Horvath, P Horvath, R Barrangou, R Jansen, RE Haurwitz, Reinhild Wurm, RH van den Heuvel, RK Lillestøl, Rolf Wagner, S Houwing, Sakharam P Waghmare, SC Raghavan, SJ Brouns, SP Waghmare, Stan J J Brouns, T Itoh, T Wilson-Sali, TA Baker, TH Tang, V Kunin, Y Agari, Ümit Pul   +71 more
core   +5 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

DNA Tumor Virus Regulation of Host DNA Methylation and Its Implications for Immune Evasion and Oncogenesis

Viruses, 2018
Viruses have evolved various mechanisms to evade host immunity and ensure efficient viral replication and persistence. Several DNA tumor viruses modulate host DNA methyltransferases for epigenetic dysregulation of immune-related gene expression in host ...
Sharon K. Kuss-Duerkop, Joseph A. Westrich, Dohun Pyeon   +2 more
doaj   +1 more source