Results 161 to 170 of about 375,102 (256)

Screening great ape museum specimens for DNA viruses. [PDF]

Sci Rep
Hämmerle M, Guellil M, Trgovec-Greif L, Cheronet O, Sawyer S, Ruiz-Gartzia I, Lizano E, Rymbekova A, Gelabert P, Bernardi P, Han S, Rattei T, Schuenemann VJ, Marques-Bonet T, Guschanski K, Calvignac-Spencer S, Pinhasi R, Kuhlwilm M.   +17 more
europepmc   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Detection of DNA Viruses in Free-Ranging Rat Populations in Hungary. [PDF]

Viruses
Vidovszky MZ, Surján A, Földvári G, Egyed L.   +3 more
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Thousands-years-old deep-sea DNA viruses reveal the evolution of human pathogenic viruses. [PDF]

J Adv Res
He T, Zhang X, Zhang X.
europepmc   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

<i>Bacilladnaviridae</i>: refined taxonomy and new insights into the biology and evolution of diatom-infecting DNA viruses. [PDF]

J Gen Virol
Varsani A, Custer JM, Cobb IN, Harding C, Collins CL, Suazo C, Schreck J, Fontenele RS, Stainton D, Dayaram A, Goldstein S, Kazlauskas D, Kraberger S, Krupovic M.   +13 more
europepmc   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Summary of taxonomy changes ratified by the International Committee on Taxonomy of Viruses (ICTV) from the Animal DNA Viruses and Retroviruses Subcommittee, 2025. [PDF]

J Gen Virol
Varsani A, Abd-Alla AMM, Arnberg N, Bateman KS, Benkő M, Bézier A, Biagini P, Bojko J, Butkovic A, Canuti M, Celer V, Drezen JM, Egyed L, Fischer MG, François S, Guinet B, Harrach B, Harrison RL, Herniou EA, Hess M, Hu J, Jehle JA, Kaján GL, Kajon AE, Koonin EV, Kraberger S, Krell PJ, Krupovic M, Kuhn JH, Lei C, Leobold M, Maggi F, Mittal SK, Okamoto H, Opriessnig T, Peng X, Pénzes J, Podgorski II, Postler TS, Ribeiro BM, San Martín C, Söderlund-Venermo M, Sun X, Surján A, Tarján ZL, Varaldi J, Vidovszky MZ, Wadell G, Watanabe H, Yutin N, van Oers MM, Ictv Taxonomy Summary Consortium, ICTV Taxonomy Summary Consortium.   +52 more
europepmc   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source