Results 191 to 200 of about 614,581 (300)

DNA Tumor Viruses [PDF]

FEBS Letters, 1982
Cavalier-Smith, T., John Tooze,
openaire   +1 more source

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source

Screening great ape museum specimens for DNA viruses. [PDF]

Sci Rep
Hämmerle M, Guellil M, Trgovec-Greif L, Cheronet O, Sawyer S, Ruiz-Gartzia I, Lizano E, Rymbekova A, Gelabert P, Bernardi P, Han S, Rattei T, Schuenemann VJ, Marques-Bonet T, Guschanski K, Calvignac-Spencer S, Pinhasi R, Kuhlwilm M.   +17 more
europepmc   +1 more source

Defning a core genome for the Herpesvirales and exploring their evolutionary relationship with the Caudovirales [PDF]

, 2019
Andrade-Martínez, Juan S., Moreno-Gallego, J. Leonardo, Reyes, Alejandro   +2 more
core   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Detection of DNA Viruses in Free-Ranging Rat Populations in Hungary. [PDF]

Viruses
Vidovszky MZ, Surján A, Földvári G, Egyed L.   +3 more
europepmc   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Thousands-years-old deep-sea DNA viruses reveal the evolution of human pathogenic viruses. [PDF]

J Adv Res
He T, Zhang X, Zhang X.
europepmc   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Summary of taxonomy changes ratified by the International Committee on Taxonomy of Viruses (ICTV) from the Animal DNA Viruses and Retroviruses Subcommittee, 2025. [PDF]

J Gen Virol
Varsani A, Abd-Alla AMM, Arnberg N, Bateman KS, Benkő M, Bézier A, Biagini P, Bojko J, Butkovic A, Canuti M, Celer V, Drezen JM, Egyed L, Fischer MG, François S, Guinet B, Harrach B, Harrison RL, Herniou EA, Hess M, Hu J, Jehle JA, Kaján GL, Kajon AE, Koonin EV, Kraberger S, Krell PJ, Krupovic M, Kuhn JH, Lei C, Leobold M, Maggi F, Mittal SK, Okamoto H, Opriessnig T, Peng X, Pénzes J, Podgorski II, Postler TS, Ribeiro BM, San Martín C, Söderlund-Venermo M, Sun X, Surján A, Tarján ZL, Varaldi J, Vidovszky MZ, Wadell G, Watanabe H, Yutin N, van Oers MM, Ictv Taxonomy Summary Consortium, ICTV Taxonomy Summary Consortium.   +52 more
europepmc   +1 more source