Results 51 to 60 of about 614,581 (300)

Evolution of the AGMK1-9T7 GLI1+ progenitor cells to become tumor cells and potentially cancer-stem cells

Advances in Cancer Biology - Metastasis
We have investigated the expression of selected genes and miRNAs that have been found to be associated with human cancer-stem cells for their involvement in the neoplastic evolution of our AGMK1-9T7 cell line from a non-tumorigenic status at passage (p ...
Andrew M. Lewis, Jr., Gideon Foseh, Keith Peden, Adovi Akue, Mark KuKuruga, Daniel Rotroff, Gladys Lewis, Ilya Mazo   +7 more
doaj   +1 more source

Exploring nucleo-cytoplasmic large DNA viruses in Tara Oceans microbial metagenomes [PDF]

, 2013
Nucleo-cytoplasmic large DNA viruses (NCLDVs) constitute a group of eukaryotic viruses that can have crucial ecological roles in the sea by accelerating the turnover of their unicellular hosts or by causing diseases in animals. To better characterize the
Acinas, Silvia G., Bork, Peer, Claverie, Jean-Michel, Clerissi, Camille, de Vargas, Colomban, Department of Applied Biological Sciences (DBIT), Vrije Universiteit Brussel, Brussels, Belgium, Department of Applied Biological Sciences (DBIT), Vrije Universiteit Brussel, Brussels, Belgium, Department of Applied Biological Sciences (DBIT), Vrije Universiteit Brussel, Brussels, Belgium, Desdevises, Yves, Faust, Karoline, Ferrera, Isabel, Grimsley, Nigel, Hingamp, Pascal, Jaillon, Olivier, Kandels-Lewis, Stefanie, Karsenti, Eric, Lima-Medez, Gipsi, Moreau, Hervé, Not, Fabrice, Ogata, Hiroyuki, Pesant, Stéphane, Poulain, Julie, Raes, Jeroen, Sarmento, Hugo, Subirana, Lucie, Sunagawa, Shinichi, Villar, Emilie, Wincker, Patrick   +27 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Evaluating the Antibiotic Resistance Patterns in Mycoplasma hominis and Ureaplasma spp. Infections in Salvador, Brazil

Venereology
Background/Objectives: Mycoplasma and Ureaplasma species are pathogens commonly associated with urogenital infections in sexually active individuals.
Sofia Lírio Santos Silva, Larissa Vieira do Amaral, Raissa Vieira do Amaral, Maria Isabel Figueiredo Sousa, Mauricio Freitas Batista, Maria Betânia Toralles, Caroline Alves Feitosa, Galileu Barbosa Costa, Viviane Matos Ferreira   +8 more
doaj   +1 more source

Cryo-EM structure of a licensed DNA replication origin

Nature Communications, 2017
Origins of replication are licensed by loading of MCM onto DNA, and origin firing depends on interaction with Cdc45 and GINS to form two CMG holo-helicases. Here, authors determine the cryo-EM structures of DNA-bound MCM and visualise a phospho-dependent
Ferdos Abid Ali, Max E. Douglas, Julia Locke, Valerie E. Pye, Andrea Nans, John F. X. Diffley, Alessandro Costa   +6 more
doaj   +1 more source

Geminivirus Rep Protein Interferes with the Plant DNA Methylation Machinery and Modifies the Host Epigenome [PDF]

, 2016
The apparent simplicity of viruses hides the complexity of their interactions with their hosts. Viruses are masters at circumventing host defenses and manipulating the cellular environment for their own benefit.
Castillo-Garriga, Araceli
core  

Virus shapes and buckling transitions in spherical shells [PDF]

, 2003
We show that the icosahedral packings of protein capsomeres proposed by Caspar and Klug for spherical viruses become unstable to faceting for sufficiently large virus size, in analogy with the buckling instability of disclinations in two-dimensional ...
A.E. Blaurock, A.E. Lobkovsky, A.E. Lobkovsky, A.G. Murzin, A.R. Bausch, D. Caspar, D.E. Smith, D.M. Salunke, D.R. Nelson, David R. Nelson, E. Cerda, F. Crick and, H. Noguchi, J.F. Conway, Jack Lidmar, Leonid Mirny, M. Carrion-Vazquez, M. Dubois, M.J. Bowick, M.S. Kellermayer, P. Steinhardt, P. Steinhardt, P.K. Sorger, P.L. Stewart, R.F. Bruinsma, S. Seung, S.C. Harrison, T.S. Baker, U. Seifert, V. Reddy, V.S. Reddy, W.C. Earnshaw, X. Yan, Y. Kantor   +33 more
core   +1 more source

The DNA Methylation Landscape of Giant Viruses [PDF]

Nature Communications, 2019
Abstract DNA methylation is an important epigenetic mark that contributes to various regulations in all domains of life. Prokaryotes use it through Restriction-Modification (R-M) systems as a host-defense mechanism against viruses. The recently discovered giant viruses are widespread dsDNA viruses infecting eukaryotes
Sandra Jeudy, Sofia Rigou, Jean-Marie Alempic, Jean-Michel Claverie, Chantal Abergel, Matthieu Legendre   +5 more
openaire   +4 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source