Results 61 to 70 of about 2,514,590 (298)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Evolution of the AGMK1-9T7 GLI1+ progenitor cells to become tumor cells and potentially cancer-stem cells

Advances in Cancer Biology - Metastasis
We have investigated the expression of selected genes and miRNAs that have been found to be associated with human cancer-stem cells for their involvement in the neoplastic evolution of our AGMK1-9T7 cell line from a non-tumorigenic status at passage (p ...
Andrew M. Lewis, Jr., Gideon Foseh, Keith Peden, Adovi Akue, Mark KuKuruga, Daniel Rotroff, Gladys Lewis, Ilya Mazo   +7 more
doaj   +1 more source

Complete Genomes of DNA Viruses in Fecal Samples from Small Terrestrial Mammals in Spain. [PDF]

Viruses
Viromics studies are allowing us to understand not only the enormous diversity of the virosphere, but also the potential threat posed by the emerging viruses.
Buigues J, Viñals A, Martínez-Recio R, Monrós JS, Sanjuán R, Cuevas JM.   +5 more
europepmc   +2 more sources

HCIV-1 and other tailless icosahedral internal membrane-containing viruses of the family Sphaerolipoviridae [PDF]

, 2017
Members of the virus family Sphaerolipoviridae include both archaeal viruses and bacteriophages that possess a tailless icosahedral capsid with an internal membrane.
Svirskaite, Julija, Hanna Oksanen, Pietilä, Maija Kaarina, Janne Ravantti, Maija Pietilä, Tatiana Demina, Janne J. Ravantti, Bamford, Dennis Henry, Tatiana A. Demina, Atanasova, Nina Sofia, Maija K. Pietilä, Julija Svirskaitė, Dennis H. Bamford, Hanna M. Oksanen, Nina Atanasova, Ravantti, Janne Juhani, Demina, Tatiana, Oksanen, Hanna Maarit, Nina S. Atanasova, Dennis Bamford   +19 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evaluating the Antibiotic Resistance Patterns in Mycoplasma hominis and Ureaplasma spp. Infections in Salvador, Brazil

Venereology
Background/Objectives: Mycoplasma and Ureaplasma species are pathogens commonly associated with urogenital infections in sexually active individuals.
Sofia Lírio Santos Silva, Larissa Vieira do Amaral, Raissa Vieira do Amaral, Maria Isabel Figueiredo Sousa, Mauricio Freitas Batista, Maria Betânia Toralles, Caroline Alves Feitosa, Galileu Barbosa Costa, Viviane Matos Ferreira   +8 more
doaj   +1 more source

Virus discovery in all three major lineages of terrestrial arthropods highlights the diversity of single-stranded DNA viruses associated with invertebrates [PDF]

PeerJ, 2018
Viruses encoding a replication-associated protein (Rep) within a covalently closed, single-stranded (ss)DNA genome are among the smallest viruses known to infect eukaryotic organisms, including economically valuable agricultural crops and livestock ...
Karyna Rosario, Kaitlin A. Mettel, Bayleigh E. Benner, Ryan Johnson, Catherine Scott, Sohath Z. Yusseff-Vanegas, Christopher C.M. Baker, Deby L. Cassill, Caroline Storer, Arvind Varsani, Mya Breitbart   +10 more
doaj   +2 more sources

Gestational Viral Infections: Role of Host Immune System

Microorganisms, 2023
Viral infections in pregnancy are major causes of maternal and fetal morbidity and mortality. Infections can develop in the neonate transplacentally, perinatally, or postnatally (from breast milk or other sources) and lead to different clinical ...
Silvia Beltrami, Sabrina Rizzo, Giovanna Schiuma, Giorgia Speltri, Dario Di Luca, Roberta Rizzo, Daria Bortolotti   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source