Results 41 to 50 of about 375,593 (258)
Mechanics of DNA packaging in viruses [PDF]
Proceedings of the National Academy of Sciences, 2003 A new generation of single-molecule experiments has opened up the possibility of reexamining many of the fundamental processes of biochemistry and molecular biology from a unique and quantitative perspective. One technique producing a host of intriguing results is the use of optical tweezers to measure the mechanical forces exerted by molecular motors ...
Purohit, Prashant K. +2 more
openaire +4 more sources
CXCL10 Chemokine: A Critical Player in RNA and DNA Viral Infections
Viruses, 2022 Chemokines constitute a group of small, secreted proteins that regulate leukocyte migration and contribute to their activation. Chemokines are crucial inflammatory mediators that play a key role in managing viral infections, during which the profile of ...
Noha Mousaad Elemam +2 more
doaj +1 more source
Pervasive Chimerism in the Replication-Associated Proteins of Uncultured Single-Stranded DNA Viruses
Viruses, 2018 Numerous metagenomic studies have uncovered a remarkable diversity of circular replication-associated protein (Rep)-encoding single-stranded (CRESS) DNA viruses, the majority of which are uncultured and unclassified. Unlike capsid proteins, the Reps show
Darius Kazlauskas +2 more
doaj +1 more source
Microbiology Spectrum, 2023 DNA replication is a standard and essential function among DNA viruses; however, this functional domain's common ancestor, origin, and evolutionary path in invertebrate- and vertebrate-infecting viruses are not yet fully understood.
Perumal Arumugam Desingu +2 more
doaj +1 more source
Full-genome sequencing of dozens of new DNA viruses found in Spanish bat feces [PDF]
Microbiology SpectrumJuan Salvador Monrós +2 more
exaly +2 more sources
The DNA Methylation Landscape of Giant Viruses [PDF]
Nature Communications, 2019 Abstract DNA methylation is an important epigenetic mark that contributes to various regulations in all domains of life. Prokaryotes use it through Restriction-Modification (R-M) systems as a host-defense mechanism against viruses. The recently discovered giant viruses are widespread dsDNA viruses infecting eukaryotes
Sandra Jeudy +5 more
openaire +4 more sources
Inhibition of histone methyltransferase SETD8 represses DNA virus replication
Cell Insight, 2022 Multiple diseases, such as cancer and neural degeneration diseases, are related with the latent infection of DNA viruses. However, it is still difficult to clean up the latent DNA viruses and new anti-viral strategies are critical for disease treatment ...
Lin Chen +6 more
doaj +1 more source
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, EarlyView.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source
Virus discovery in all three major lineages of terrestrial arthropods highlights the diversity of single-stranded DNA viruses associated with invertebrates [PDF]
PeerJ, 2018 Viruses encoding a replication-associated protein (Rep) within a covalently closed, single-stranded (ss)DNA genome are among the smallest viruses known to infect eukaryotic organisms, including economically valuable agricultural crops and livestock ...
Karyna Rosario +10 more
doaj +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan +3 more
wiley +1 more source