Results 41 to 50 of about 2,514,590 (298)

Viral Hybrid Vectors for Somatic Integration - Are They the Better Solution? [PDF]

open access: yes, 2009
The turbulent history of clinical trials in viral gene therapy has taught us important lessons about vector design and safety issues. Much effort was spent on analyzing genotoxicity after somatic integration of therapeutic DNA into the host genome. Based
Anja Ehrhardt   +6 more
core   +1 more source

Pervasive Chimerism in the Replication-Associated Proteins of Uncultured Single-Stranded DNA Viruses

open access: yesViruses, 2018
Numerous metagenomic studies have uncovered a remarkable diversity of circular replication-associated protein (Rep)-encoding single-stranded (CRESS) DNA viruses, the majority of which are uncultured and unclassified. Unlike capsid proteins, the Reps show
Darius Kazlauskas   +2 more
doaj   +1 more source

Discovery and Characterization of Actively Replicating DNA and Retro-Transcribing Viruses in Lower Vertebrate Hosts Based on RNA Sequencing

open access: yes, 2021
In a previous study, a metatranscriptomics survey of RNA viruses in several important lower vertebrate host groups revealed huge viral diversity, transforming the understanding of the evolution of vertebrate-associated RNA virus groups.
Xin-Xin Chen, Mang Shi, Wei-Chen Wu
core   +1 more source

Neutralizing and protective monoclonal antibodies identify antigenic sites in influenza H7 hemagglutinin and select for amino acid substitutions rarely observed at the global level

open access: yesMicrobiology Spectrum
Avian influenza viruses of the H7 subtype infect a variety of avian as well as mammalian species, and a better understanding of H7 virus antigenicity and immunogenicity is vital to the development of effective countermeasures for a potential H7 pandemic ...
Gabriel I. Parra   +10 more
doaj   +1 more source

Genetic and antigenic characterization of avian influenza H9N2 viruses during 2016 in Iraq [PDF]

open access: yesOpen Veterinary Journal, 2019
Background: Little is known about the antigenic and genetic characteristics of influenza A viruses (IAVs) circulating in poultry in Iraq. Objective: This study describes the genetic and antigenic characteristics of the detected avian influenza (AI ...
Nadira S. Mohamed   +4 more
doaj   +1 more source

Bacteriophages and their structural organisation [PDF]

open access: yes, 2012
Viruses are extremely small infectious particles that are not visible in a light microscope, and are able to pass through fine porcelain filters. They exist in a huge variety of forms and infect practically all living systems: animals, plants ...
E.V. Orlova, Orlova, Elena
core   +1 more source

Modern taxonomy of viruses of vertebrates

open access: yesНауковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки, 2020
The modern taxonomy of viruses of vertebrates is presented according to the information of ICTV issue 07.2019, ratification 03.2020. The leading criteria of taxonomy of viruses are named: type and structure of viral genome, mechanism of replication and ...
O. S. Kalinina
doaj   +1 more source

Diversity and evolution of novel invertebrate DNA viruses revealed by meta-transcriptomics [PDF]

open access: yes, 2019
DNA viruses comprise a wide array of genome structures and infect diverse host species. To date, most studies of DNA viruses have focused on those with the strongest disease associations.
John-Sebastian Eden   +9 more
core   +1 more source

Towards quantitative viromics for both double-stranded and single-stranded DNA viruses [PDF]

open access: yesPeerJ, 2016
Background Viruses strongly influence microbial population dynamics and ecosystem functions. However, our ability to quantitatively evaluate those viral impacts is limited to the few cultivated viruses and double-stranded DNA (dsDNA) viral genomes ...
Simon Roux   +8 more
doaj   +2 more sources

The DNA Methylation Landscape of Giant Viruses [PDF]

open access: yesNature Communications, 2019
Abstract DNA methylation is an important epigenetic mark that contributes to various regulations in all domains of life. Prokaryotes use it through Restriction-Modification (R-M) systems as a host-defense mechanism against viruses. The recently discovered giant viruses are widespread dsDNA viruses infecting eukaryotes
Sandra Jeudy   +5 more
openaire   +4 more sources

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