Results 21 to 30 of about 2,514,590 (298)
Contribution of hypoxia inducible factor-1 during viral infections
Virulence, 2020 Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that plays critical roles during the cellular response to hypoxia. Under normoxic conditions, its function is tightly regulated by the degradation of its alpha subunit (HIF-1α), which impairs ...
Antonia Reyes +5 more
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Systematic CpT (ApG) depletion and CpG excess are unique genomic signatures of large DNA viruses infecting invertebrates. [PDF]
PLoS ONE, 2014 Differences in the relative abundance of dinucleotides, if any may provide important clues on host-driven evolution of viruses. We studied dinucleotide frequencies of large DNA viruses infecting vertebrates (n = 105; viruses infecting mammals = 99 ...
Mohita Upadhyay +2 more
doaj +1 more source
Cell Reports: Methods, 2022 Summary: The development of a chemically attenuated, replication-incompetent virus vaccine can provide protection against diseases caused by DNA viruses.
Dabbu Kumar Jaijyan +3 more
doaj +1 more source
Oncogene, 2001 The early discoveries of Gross (1951) of viral causation of murine leukemias, the subsequent demonstration of retroviruses as the causative factors and the presence of similar viruses particularly in lymphoproliferative disorders in cattle, cats, and various rodent species, underlined for decades the justi®cation of attempts to search for similar ...
openaire +2 more sources
Three-Dimensional Architecture of the Human BRCA1-A Histone Deubiquitinase Core Complex
Cell Reports, 2016 BRCA1 is a tumor suppressor found to be mutated in hereditary breast and ovarian cancer and plays key roles in the maintenance of genomic stability by homologous recombination repair.
Otto J.P. Kyrieleis +9 more
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Microbiology Spectrum, 2023 DNA replication is a standard and essential function among DNA viruses; however, this functional domain's common ancestor, origin, and evolutionary path in invertebrate- and vertebrate-infecting viruses are not yet fully understood.
Perumal Arumugam Desingu +2 more
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Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion
Pathogens, 2019 The nine human herpesviruses are some of the most ubiquitous pathogens worldwide, causing life-long latent infection in a variety of different tissues. Human herpesviruses range from mild childhood infections to known tumour viruses and ‘trolls of ...
Charlotte J. Houldcroft
doaj +1 more source
First Report on Detection and Complete Genomic Analysis of a Novel CRESS DNA Virus from Sea Turtles
Pathogens, 2023 To date, only a handful of viruses have been identified in sea turtles. Although eukaryotic circular Rep (replication initiation protein)-encoding single-stranded DNA (CRESS DNA) viruses have been reported from a wide variety of terrestrial species, and ...
Kerry Gainor +8 more
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Exploring nucleo-cytoplasmic large DNA viruses in Tara Oceans microbial metagenomes [PDF]
, 2013 Nucleo-cytoplasmic large DNA viruses (NCLDVs) constitute a group of eukaryotic viruses that can have crucial ecological roles in the sea by accelerating the turnover of their unicellular hosts or by causing diseases in animals. To better characterize the
Moreau, Hervé +25 more
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Interplay between the DNA damage response and the life cycle of DNA tumor viruses
Tumour Virus Research, 2023 Approximately 20 % of human cancers are associated with virus infection. DNA tumor viruses can induce tumor formation in host cells by disrupting the cell's DNA replication and repair mechanisms. Specifically, these viruses interfere with the host cell's
Caleb J. Studstill +2 more
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