Results 271 to 280 of about 697,276 (400)

AN INVESTIGATION INTO THE THEORY AND PRACTICE OF HYDRAULIC MORTAR, AS MADE ON THE NEW WORKS OF THE LONDON DOCK COMPANY, 1856-57. (INCLUDING APPENDIX). [PDF]

Gordon G. Robertson
openalex   +1 more source

DISCUSSION. KING GEORGE DOCK, HULL : MAJOR DEVELOPMENTS, 1959-1963. [PDF]

, 1964
D G MCGAREY, William G. Harris, J H JELLETT, J E G PALMER, Roberta Edwards, Germanischer Lloyd, H R BOYCE, FA PAGE, G A WILSON, G A WRIGLEY   +9 more
openalex   +1 more source

Improved protein–ligand docking using GOLD

Proteins: Structure, Function, and Bioinformatics, 2003
M. Verdonk, J. Cole, M. Hartshorn, C. Murray, Richard D. Taylor   +4 more
semanticscholar   +1 more source

Novel Cyano‐Artemisinin Dimer ZQJ29 Targets PARP1 to Induce Ferroptosis in Pancreatic Cancer Treatment

Advanced Science, EarlyView.
A novel artemisinin derivative dimer has been synthesized, and its significant potential as an anti‐cancer agent. The study indicated that ZQJ29 effectively inhibited the proliferation of pancreatic cancer cells in vitro and in vivo. Additionally, these investigations have unveiled ZQJ29 as a new potent PARP1 inhibitor, with the capability to induce ...
Jianping Chen, Lingyun Yue, Yanna Pan, Bingying Jiang, Junfeng Wan, Haixia Lin, Fujiang Guo, Huiyu Li, Yajuan Li, Qingjie Zhao   +9 more
wiley   +1 more source

Unveiling Isorhapontigenin's therapeutic potential in lung cancer via integrated network pharmacology, molecular docking, and experimental validation. [PDF]

Sci Rep
Wu Z, Hou C, Zhu Q, Huang Z, Lu Z, Shen C, Wang Z, Liu Y, Kang Y, Wang J.   +9 more
europepmc   +1 more source

Nephronectin (NPNT) is a Crucial Determinant of Idiopathic Pulmonary Fibrosis: Modulating Cellular Senescence via the ITGA3/YAP1 Signaling Axis

Advanced Science, EarlyView.
Through a comprehensive multi‐omics analysis, this study identifies a marked reduction in Nephronectin (NPNT) expression within fibrotic lung tissue. This reduction impairs the binding capability to the ITGA3 receptor, consequently causing YAP1 to persist in the cytoplasm, where it undergoes degradation.
Jiayu Guo, Yan Wang, Qiudi Liu, Zhaoyang Luo, Xiaomu Tian, Yuquan Wang, Yang Liu, Zhiwei Ning, Yingying Guo, Huiying Gao, Xinyue Wang, Jinglong Feng, Mengmeng Liu, Dina Saifullina, Yixin Zhang, Tengfei Pan, Yu Bian, Tao Ban, Tianyu Li, Yunyan Gu, Haihai Liang   +20 more
wiley   +1 more source

Oppenheimer in Dock [PDF]

, 1971
William Cooper
openalex   +1 more source

Molecular Docking and Molecular Dynamics Study of Propolis Compounds of Sulabiroin-A, Sulabiroin-B, and Broussoflavonol F Toward Tuberculosis 3PTY Target Protein. [PDF]

J Trop Med
Fatriansyah JF, Pradana AF, Driasaditya A, Sinaga AA, Sahlan M, Surip SN.   +5 more
europepmc   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

High-Risk Neuroblastoma Stage 4 (NBS4): Developing a Medicinal Chemistry Multi-Target Drug Approach. [PDF]

Molecules
Gerges A, Canning U.
europepmc   +1 more source