Design, Synthesis, Evaluation, and Molecular Docking Study of Ascorbic Acid Dual-Coated Omeprazole Pellets and the Antioxidative Effect of Ascorbic Acid on Omeprazole-Induced Renal Injury in an Animal Model [PDF]
ACS Omega, 2023 The present study was carried out to investigate the antioxidant effect of ascorbic acid on omeprazole (O.P.)-induced acute kidney infection (AKI). Design of experiment (DoE) was employed to fabricate formulations (P1-P8) by the extrusion spheronization technique, and they were evaluated using various analytical techniques.
Hina Raza +8 more
openaire +4 more sources
Biomedicine & Pharmacotherapy, 2023 The use of NSAIDs have caused stomach injury by inhibiting endogenous mucosal prostaglandin production. Cucumis melo is reported to possess antiulcer potential. This study investigates the mechanism underlying the antiulcer potentials of Cucumis melo (CUM).Thirty-five male Wistar rat were randomly assigned to each of seven groups; A(control given water
Grace, Adebayo-Gege +10 more
openaire +3 more sources
Scientific Reports, 2023 To investigate the potential mechanism of resveratrol in anti-fatigue by network pharmacology and molecular docking, and to investigate the anti-fatigue efficacy of resveratrol through in vitro animal experiments.
Peipei Ma +5 more
doaj +2 more sources
Integration of bioinformatics analysis, molecular docking and animal experiments to study the therapeutic mechanisms of berberine against allergic rhinitis [PDF]
Scientific ReportsAbstractAllergic rhinitis is a prevalent inflammatory condition that impacts individuals of all age groups. Despite reports indicating the potential of berberine in alleviating allergic rhinitis symptoms, the specific molecular mechanisms and therapeutic targets of berberine remain unclear. This research aims to explore the pharmacological mechanism of
Gaoqing Luo, Ming Gao, Qinghua Lin
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Molecular docking, simulations of animal peptides against the envelope protein of Dengue virus
Journal of Biomolecular Structure and Dynamics, 2023 Peptides are biologically active, small molecules with high specificity in its mode of action that can be effective at nanomolar concentrations. Peptide-based antiviral medicines have already been licensed and used to treat human immunodeficiency virus (HIV), influenza virus and hepatitis C virus. So far, no peptide drug has been approved for antiviral
Reena, Guntamadugu +3 more
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The risks associated with tail biting in pigs and possible means to reduce the need for tail docking considering the different housing and husbandry systems - Scientific Opinion of the Panel on Animal Health and Welfare [PDF]
EFSA Journal, 2007 The Panel on Animal Health and Welfare was asked to deliver a Scientific Opinion on the risks associated with tail biting in pigs and possible means to reduce the need for tail docking considering the different housing and husbandry ...
Blokhuis, H.J. +8 more
openaire +3 more sources
Hispidin and Lepidine E: two Natural Compounds and Folic acid as Potential Inhibitors of 2019-novel coronavirus Main Protease (2019-nCoVMpro), molecular docking and SAR study [PDF]
arXiv, 2020 2019-nCoV is a novel coronavirus was isolated and identified in 2019 in Wuhan, China. On 17th February and according to world health organization, a number of 71 429 confirmed cases worldwide, among them 2162 new cases recorded in the last 24 hours. There is no drug or vaccine for human and animal coronavirus.
Talia Serseg, K. Benarous, M. Yousfi
arxiv +2 more sources
Circulating microRNA profiles are associated with acute pain and stress in castrated and tail docked lambs [PDF]
Veterinary and Animal ScienceMaintaining animal welfare is an essential component of animal production systems. However, multiple measurements are required to inform an animal's welfare state as there are currently no universal measurement tools.
Ryan J. Farr +7 more
doaj +2 more sources
Exploring anti-nonalcoholic fatty liver disease mechanism of Gardeniae Fructus by combining an animal model with network pharmacology and molecular docking [PDF]
, 2020 Abstract Background Gardeniae Fructus (GF), a traditional Chinese medicine in clinic for the treatment of nonalcoholic fatty liver disease (NAFLD). However, the mechanisms of action of GF was still margin. To explore the efficacy and mechanism of action of GF for the treatment of NAFLD, we proposed a strategy combined in vivo efficacy ...
Lin Li +3 more
openaire +3 more sources
Animal WelfareTail docking is a husbandry practice widely incorporated in sheep farms around the world. It is an irreversible mutilation that impairs animal welfare, both immediately and in the longer term.
Giuliano Pereira de Barros +4 more
doaj +2 more sources