Results 11 to 20 of about 133,738 (306)

Acclimation and Blood Sampling: Effects on Stress Markers in C57Bl/6J Mice

Animals, 2023
Blood sampling in rodents is common practice in scientific studies. Some of the refined methods widely used are the puncture of the saphenous vein or tail vein, or even tail docking.
Nerea Marin, Amparo Moragon, Domingo Gil, Francisco Garcia-Garcia, Viviana Bisbal   +4 more
doaj   +1 more source

Harmonization of welfare standards for the protection of pigs with the EU-rules: the case of Croatia [PDF]

, 2009
Three quarters of Croatian pigs are produced in small production units (1-5 sows) and on family farms with mixed farming activities. Only few farms have specialized production units with up-to-date technologies and comply with EU standards.
Antunovic, B., Bock, B.B., Kralik, G., Oosting, S.J., Wellbrock, W.   +4 more
core   +5 more sources

Ganoderic acid C2 exerts the pharmacological effects against cyclophosphamide-induced immunosuppression: a study involving molecular docking and experimental validation

Scientific Reports, 2023
Triterpenoids, as the main active ingredient of Ganoderma lucidum fermented extract, exert multiple pharmacological activities, including immunomodulatory properties.
Yuchen Liu, Dongsheng Tan, Hong Cui, Jihua Wang   +3 more
doaj   +1 more source

The Mechanism of Mori Folium and Eucommiae Cortex against Cyclophosphamide-Induced Immunosuppression Integrating Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and Experimental Validation

Metabolites, 2023
It has been reported that Mori Folium (MF) and Eucommiae Cortex (EC) exhibit pharmacological effects in the treatment of immunosuppression. However, the mechanism of MF and EC against immunosuppression remains unclear.
Jinde Liu, Qiao Rong, Chunxiao Zhang, Ali Tariq, Lin Li, Yongning Wu, Feifei Sun   +6 more
doaj   +1 more source

Ecdysteroids: A novel class of anabolic agents? [PDF]

, 2015
Increasing numbers of dietary supplements with ecdysteroids are marketed as “natural anabolic agents”. Results of recent studies suggested that their anabolic effect is mediated by estrogen receptor (ER) binding. Within this study the anabolic potency of
BOTRE', Francesco, Parr, M. K.,  Diel, P,  Hengevoss, J.,  Naß, A,  Wolber G.   +5 more
core   +2 more sources

Design, synthesis and evaluation of novel 3,5-disubstituted benzamide derivatives as allosteric glucokinase activators

BMC Chemistry, 2019
Glucokinase (GK) is the key enzyme expressed in β-cells of pancreas and liver hepatocytes and helps in the maintenance of blood glucose levels in normal range.
Ajmer Singh Grewal, Rajeev Kharb, Deo Nandan Prasad, Jagdeep Singh Dua, Viney Lather   +4 more
doaj   +1 more source

Effect of previous handling experiences on responses of dairy calves to routine husbandry procedures [PDF]

, 2013
The nature of human–animal interactions is an important factor contributing to animal welfare and productivity. Reducing stress during routine husbandry procedures is likely to improve animal welfare.
McLeay, Lance M., Schütz, K.E., Shepherd, Haley Marie, Stewart, Mairi, Waas, Joseph R., Webster, J.R.   +5 more
core   +2 more sources

Tail docking in horses: a review of the issues

Animal, 2007
Routinely performed painful procedures are of increasing interest and, in 2001 (Royal Order, May 17), Belgium prohibited docking in several vertebrates including horses. In 2004, opponents to this decision submitted a Bill (Doc51 0969/001) to Parliament,
D. Lefebvre, D. Lips, F.O. Ödberg, J.M. Giffroy   +3 more
doaj   +1 more source

Analysis of Housing Risk Factors for the Welfare of Lean and Heavy Pigs in a Sample of European Fattening Farms

Animals, 2021
Pig welfare is affected by housing conditions, the minimum requirements of which are set up by EU legislation. Animal and non-animal-based measures are useful indicators to investigate housing risk factors for pig welfare.
Paolo Ferrari, Alessandro Ulrici, Matteo Barbari   +2 more
doaj   +1 more source

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma. [PDF]

, 2019
Dysregulation of the seven-transmembrane (7TM) receptor Smoothened (SMO) and other components of the Hedgehog (Hh) signaling pathway contributes to the development of cancers including basal cell carcinoma (BCC) and medulloblastoma (MB).
Abagyan, Ruben, Chahal, Kirti Kandhwal, Chen, Clark C, Durden, Donald L, Kufareva, Irina, Li, Jie, Parle, Milind, Wechsler-Reya, Robert J   +7 more
core   +1 more source